日本早产儿临床核黄疸的当前发病率。

Current incidence of clinical kernicterus in preterm infants in Japan.

作者信息

Morioka Ichiro, Nakamura Hajime, Koda Tsubasa, Yokota Tomoyuki, Okada Hitoshi, Katayama Yoshinori, Kunikata Tetsuya, Kondo Masatoshi, Nakamura Makoto, Hosono Shigeharu, Yasuda Saneyuki, Yokoyama Naoki, Wada Hiroshi, Itoh Susumu, Funato Masahisa, Yamauchi Yoshitada, Lee Yong Kye, Yonetani Masahiko

机构信息

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe.

Japan Neonatal Jaundice Study Group, Japan.

出版信息

Pediatr Int. 2015 Jun;57(3):494-7. doi: 10.1111/ped.12651.

DOI:10.1111/ped.12651

PMID:26113317

Abstract

Clinical kernicterus in preterm infants has recently been reported in Japan, diagnosed on the basis of clinical findings during the neonatal and infancy periods. We investigated the incidence of clinical kernicterus in preterm infants <30 weeks gestational age (GA) based on a nationwide survey conducted in 233 certified educational facilities for neonatologists. The numbers of infants admitted and infants who died within 14 days after birth during 2011, and the number of infants who subsequently developed clinical kernicterus, were recorded. A total of 2720 infants were analyzed, representing 59% (2720/4623) of all preterm live births <30 weeks GA in Japan in 2011. Of these, 159 (5.8%) died within 14 days after birth, similar to the national rate. Five infants developed clinical kernicterus in infancy (5/2720, 0.18%). The current incidence of clinical kernicterus in Japan is therefore estimated at 1.8 per 1000 live births <30 weeks GA.

摘要

日本最近报道了早产儿的临床核黄疸病例，其诊断依据是新生儿期和婴儿期的临床表现。我们基于对233家认证的新生儿科医生教育机构进行的全国性调查，对孕周小于30周（GA）的早产儿临床核黄疸的发病率进行了调查。记录了2011年出生后14天内入院的婴儿数量、死亡的婴儿数量以及随后发生临床核黄疸的婴儿数量。总共分析了2720名婴儿，占2011年日本所有孕周小于30周的早产活产婴儿的59%（2720/4623）。其中，159名（5.8%）在出生后14天内死亡，与全国死亡率相似。5名婴儿在婴儿期发生了临床核黄疸（5/2720，0.18%）。因此，日本目前孕周小于30周的早产活产婴儿临床核黄疸的发病率估计为每1000例中有1.8例。