Protasiewicz Marcin, Początek Karol, Podgórski Maciej, Poręba Rafał, Derkacz Arkadiusz, Gosławska Katarzyna, Kwiatkowska Wiesława, Mazur Grzegorz, Mysiak Andrzej, Januszewicz Andrzej
Department of Cardiology, Medical University of Wrocław , Wrocław , Poland.
Blood Press. 2015;24(5):293-7. doi: 10.3109/08037051.2015.1053205. Epub 2015 Jun 26.
The purpose of this study was to assess the vasoconstrictive effects of adenosine in the kidney microcirculation in hypertensive patients with renal artery stenosis (RAS). Twelve patients with resistant hypertension and moderate RAS were selected for the study. In all patients, systolic, diastolic and mean translesional pressure gradients, distal pressure (Pd), aortic pressure (Pa) and Pd/Pa ratio were measured using a pressure guidewire at baseline and after intrarenal bolus administration of 400 μg adenosine. We observed significant changes in mean translesional pressure gradient and systolic Pd after pharmacological stimulation. The results suggest that in hypertensive patients with RAS, vasomotor activity of the kidney microcirculation may be preserved.
本研究的目的是评估腺苷对肾动脉狭窄（RAS）高血压患者肾脏微循环的血管收缩作用。选取12例顽固性高血压合并中度RAS患者进行研究。在所有患者中，使用压力导丝在基线时以及肾内推注400μg腺苷后，测量收缩压、舒张压和平均跨病变压力梯度、远端压力（Pd）、主动脉压力（Pa）以及Pd/Pa比值。我们观察到药物刺激后平均跨病变压力梯度和收缩期Pd有显著变化。结果表明，在患有RAS的高血压患者中，肾脏微循环的血管舒缩活动可能得以保留。
Zotero 插件