IGF2BP2、KCNQ1和GCKR基因多态性对EOF方案治疗转移性胃癌临床结局的影响。
Effects of IGF2BP2, KCNQ1 and GCKR polymorphisms on clinical outcome in metastatic gastric cancer treated with EOF regimen.
作者信息
Liu Xin, Chen Zhiyu, Zhao Xiaoying, Huang Mingzhu, Wang Chenchen, Peng Wei, Yin Jiliang, Li Jin, He Guang, Li Xin, Zhu Xiaodong
机构信息
Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
出版信息
Pharmacogenomics. 2015;16(9):959-70. doi: 10.2217/pgs.15.49. Epub 2015 Jun 26.
AIM
The present study analyzed Type 2 diabetes mellitus (T2D)-related gene polymorphisms and their impacts on chemotherapeutic response and survival in patients with metastatic gastric cancer (MGC).
PATIENTS & METHODS: This retrospective study enrolled 108 MGC patients treated with first-line EOF chemotherapy (epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy). Eleven single nucleotide polymorphisms of five T2D-related genes were determined.
RESULTS
Among the 11 single nucleotide polymorphisms, three (IGF2BP2 rs4402960, IGF2BP2 rs6769511 and KCNQ1 rs163182) were significantly associated with disease control rate and two (GCKR rs780093 and rs780094) were significantly associated with progression-free and overall survival.
CONCLUSION
Our results suggest IGF2BP2 and KCNQ1 polymorphisms might be independent predictors of chemotherapeutic response, while GCKR polymorphisms might be independent predictors of survival in MGC patients treated with first-line EOF chemotherapy. Original submitted 30 June 2014; revision submitted 15 April 2015.
目的
本研究分析了2型糖尿病（T2D）相关基因多态性及其对转移性胃癌（MGC）患者化疗反应和生存的影响。
患者与方法
本回顾性研究纳入了108例接受一线EOF化疗（表柔比星、奥沙利铂和5-氟尿嘧啶联合化疗）的MGC患者。测定了5个T2D相关基因的11个单核苷酸多态性。
结果
在11个单核苷酸多态性中，3个（IGF2BP2 rs4402960、IGF2BP2 rs6769511和KCNQ1 rs163182）与疾病控制率显著相关，2个（GCKR rs780093和rs780094）与无进展生存期和总生存期显著相关。
结论
我们的结果表明，IGF2BP2和KCNQ1基因多态性可能是一线EOF化疗的MGC患者化疗反应的独立预测指标，而GCKR基因多态性可能是其生存的独立预测指标。原始稿件于2014年6月30日提交；修订稿于2015年4月15日提交。
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