高浓度氧通气对胃肠吻合口强度的影响。

The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis.

作者信息

Eker Tevfik, Genc Volkan, Sevim Yusuf, Cumaogullari Ozge, Ozcelik Menekse, Kocaay Akin Firat, Ensari Cemal Özben, Pasaoglu Ozge Tugce

机构信息

Department of General Surgery, Ankara University Medical School, Ankara, Turkey.

Department of General Surgery, Ankara Penal Institution Campus State Hospital, Ankara, Turkey.

出版信息

Ann Surg Treat Res. 2015 Jul;89(1):17-22. doi: 10.4174/astr.2015.89.1.17. Epub 2015 Jun 11.

DOI:10.4174/astr.2015.89.1.17

PMID:26131440

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4481027/

Abstract

PURPOSE

The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses.

METHODS

Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats and assigned to an oxygen/nitrous oxide mixture with a fraction of inspired oxygen of 30% in groups 1 and 3 and 80% in groups 2 and 4. The measurements of perianastomotic tissue oxygen pressure, bursting pressure, level of hydroxyproline were evaluated and compared in all groups.

RESULTS

The perianastomotic tissue oxygen pressures, bursting pressures and levels of hydroxyproline were identified as significantly high in groups 2 and 4, administered a fraction of inspired oxygen of 80%, compared to groups 1 and 3, administered a fraction of inspired oxygen of 30%.

CONCLUSION

Perioperative supplemental oxygen contributes positively to the anastomotic healing.

摘要

目的

本研究旨在评估围手术期补充氧气对吻合口的影响。

方法

本研究使用了40只雄性Wistar白化大鼠，并将其随机分为4组。第3组和第4组建立了缺血再灌注模型。所有大鼠均进行空肠空肠吻合术，并在第1组和第3组给予吸入氧分数为30%的氧气/氧化亚氮混合物，在第2组和第4组给予吸入氧分数为80%的氧气/氧化亚氮混合物。评估并比较了所有组的吻合口周围组织氧分压、破裂压力、羟脯氨酸水平。