乙型肝炎病毒感染中的免疫反应
Immune Response in Hepatitis B Virus Infection.
作者信息
Tan Anthony, Koh Sarene, Bertoletti Antonio
机构信息
Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857.
Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609.
出版信息
Cold Spring Harb Perspect Med. 2015 Jul 1;5(8):a021428. doi: 10.1101/cshperspect.a021428.
Abstract
Hepatitis B virus (HBV) can replicate within hepatocytes without causing direct cell damage. The host immune response is, therefore, not only essential to control the spread of virus infection, but it is also responsible for the inflammatory events causing liver pathologies. In this review, we discuss how HBV deals with host immunity and how we can harness it to achieve virus control and suppress liver damage.
摘要
乙型肝炎病毒（HBV）可在肝细胞内复制而不引起直接细胞损伤。因此，宿主免疫反应不仅对于控制病毒感染的传播至关重要，而且还导致了引起肝脏病变的炎症事件。在本综述中，我们讨论了HBV如何应对宿主免疫以及我们如何利用宿主免疫来实现病毒控制和抑制肝脏损伤。
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