Park Jin-Ah, Fredberg Jeffrey J, Drazen Jeffrey M
Harvard T. H. Chan School of Public Health, Boston, Massachussetts.
Harvard T. H. Chan School of Public Health, Boston, Massachussetts
Physiology (Bethesda). 2015 Jul;30(4):293-303. doi: 10.1152/physiol.00004.2015.
Asthma is characterized by chronic inflammation, airway hyperresponsiveness, and progressive airway remodeling. The airway epithelium is known to play a critical role in the initiation and perpetuation of these processes. Here, we review how excessive epithelial stress generated by bronchoconstriction is sufficient to induce airway remodeling, even in the absence of inflammatory cells.
哮喘的特征是慢性炎症、气道高反应性和进行性气道重塑。已知气道上皮在这些过程的启动和持续中起关键作用。在此,我们综述了即使在没有炎症细胞的情况下,支气管收缩产生的过度上皮应激如何足以诱导气道重塑。