Ichinose Junji, Nagayama Kazuhiro, Hino Haruaki, Nitadori Jun-ichi, Anraku Masaki, Murakawa Tomohiro, Nakajima Jun
Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Eur J Cardiothorac Surg. 2016 Apr;49(4):1132-6. doi: 10.1093/ejcts/ezv256. Epub 2015 Jul 8.
The outcome of surgical treatment for secondary spontaneous pneumothorax (SSP) has rarely been investigated.
We retrospectively reviewed 183 patients who underwent surgery for SSP. We categorized the patients into three groups according to underlying diseases: Group A (chronic obstructive pulmonary disease), Group B (interstitial pneumonia [IP]) and Group C (others). We defined treatment success as surgery without hospital mortality, postoperative complications, death within 6 months or ipsilateral recurrence of pneumothorax within 2 years. We assessed the risk factors for unsuccessful treatment using a Cox regression hazard model.
There were 123 patients in Group A, 20 in Group B and 40 in Group C. The hospital mortality rates were 2, 15 and 0% in Groups A, B and C, respectively. The hospital mortality, morbidity and pneumothorax recurrence rates in the IP group were higher than in the other groups. The 5-year overall survival rates were 78, 32 and 84% in Groups A, B and C, respectively; the prognosis of the IP group was significantly poorer. The treatment success rates were 86, 45 and 83% in Groups A, B and C, respectively. SSPs caused by IP and SSPs requiring open surgery were identified as the risk factors for unsuccessful treatment.
Surgery for SSP caused by underlying diseases other than IP yielded favourable results. However, a careful examination of surgical indication and a realistic disclosure for informed consent are required for patients with SSP caused by IP, because of the high treatment failure rate.
继发性自发性气胸(SSP)手术治疗的结果鲜有研究。
我们回顾性分析了183例行SSP手术的患者。根据基础疾病将患者分为三组:A组(慢性阻塞性肺疾病)、B组(间质性肺炎[IP])和C组(其他)。我们将治疗成功定义为手术无医院死亡、术后并发症、6个月内死亡或2年内同侧气胸复发。我们使用Cox回归风险模型评估治疗失败的风险因素。
A组有123例患者,B组有20例,C组有40例。A、B、C组的医院死亡率分别为2%、15%和0%。IP组的医院死亡率、发病率和气胸复发率高于其他组。A、B、C组的5年总生存率分别为78%、32%和84%;IP组的预后明显较差。A、B、C组的治疗成功率分别为86%、45%和83%。由IP引起的SSP以及需要开胸手术的SSP被确定为治疗失败的风险因素。
由IP以外的基础疾病引起的SSP手术取得了良好的效果。然而,由于治疗失败率高,对于由IP引起的SSP患者,需要仔细检查手术指征并进行现实的知情同意告知。