无金属条件下利用 TCCA 直接氧化醛为酯。
Metal-Free Direct Oxidation of Aldehydes to Esters Using TCCA.
机构信息
†Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
‡Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
出版信息
Org Lett. 2015 Aug 7;17(15):3666-9. doi: 10.1021/acs.orglett.5b01579. Epub 2015 Jul 10.
Aromatic and aliphatic aldehydes are simply converted into esters by an efficient oxidative esterification carried out under mild conditions. The aldehydes are converted in situ into their corresponding acyl chlorides, which are then reacted with primary and secondary aliphatic, benzylic, allylic, and propargylic alcohols and phenols. A variety of esters are obtained in high yields.
芳香族和脂肪族醛在温和条件下通过高效氧化酯化反应可简单地转化为酯。醛就地转化为相应的酰氯，然后与伯、仲脂肪族、苄基、烯丙基和炔丙醇以及酚反应。各种酯以高收率得到。
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