三名多发性骨髓瘤患者继发淋巴细胞白血病：病例报告及文献复习
Three patients with multiple myeloma developing secondary lymphoblastic leukemia: case reports and review of the literature.
作者信息
Junxun Li, Junru Liu, Meilan Chen, Chujia Liang, Shaoqian Chen, Jieyu Zhan, Zhuangjian Ye, Fan Zhang, Juan Ouyang, Jing Cheng, Juan Li
机构信息
Department of Laboratory Science, First Affiliated Hospital of Sun Yatsen University, Guangzhou - China.
Department of Hematology, First Affiliated Hospital of Sun Yatsen University, Guangzhou - China.
出版信息
Tumori. 2016 Nov 11;102(Suppl. 2):28C6A97F-2EE8-4959-928C-49BCCF0E25DA. doi: 10.5301/tj.5000377.
INTRODUCTION
Secondary lymphoblastic leukemia has been rarely reported in patients with multiple myeloma.
CASE REPORTS
We report 3 cases of secondary lymphoblastic leukemia in multiple myeloma patients. They shared a similar phenotype of myeloma cells and secondary lymphoblasts. The chemotherapy treatments in the 3 patients were complex due to various factors.
CONCLUSIONS
Multiple immune defects caused by exposure to a variety of agents can play an important role in the development of secondary lymphoblastic leukemia. Microscopic morphology and flow cytometry are important means to detect secondary malignancies in multiple myeloma. Further clinical, experimental and genetic studies of secondary malignancies in multiple myeloma will be necessary in the future.
引言
继发性淋巴细胞白血病在多发性骨髓瘤患者中鲜有报道。
病例报告
我们报告3例多发性骨髓瘤患者发生继发性淋巴细胞白血病的病例。骨髓瘤细胞和继发性淋巴母细胞具有相似的表型。由于多种因素，这3例患者的化疗治疗较为复杂。
结论
接触多种因素导致的多重免疫缺陷在继发性淋巴细胞白血病的发生中可能起重要作用。显微镜形态学和流式细胞术是检测多发性骨髓瘤继发性恶性肿瘤的重要手段。未来有必要对多发性骨髓瘤继发性恶性肿瘤进行进一步的临床、实验和遗传学研究。
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