Mohamed A M, el-Sharief A M, Ammar Y A, Aly M M
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo.
Pharmazie. 1989 Nov;44(11):765-7.
1,3-Diphenyl-4-thione-2,5-imidazolidinedione (3) was reacted with amino compounds and o-diamines to give 1,3-diphenyl-4-substituted imino-2,5-imidazolinediones (4a-m) and 1,3-diphenyl-1H-imidazo[4,5-b]quinoxaline-2(3H)-ones (5a-c), respectively. Condensation of 3 with hydrazines afforded the corresponding hydrazone derivatives (6a-c). Reaction of 6a with acetyl chloride, aromatic aldehydes, arylsulphonyl chlorides, phthalic acid anhydrides and isocyanates or thiocyanates furnished 6d, furnished the acetyl-amido derivative 6b, the benzylidenimino derivatives 7a-d, the arylsulphonamido derivatives 8a-b, the phthalimido derivatives 9a-b and the ureido and thioureido derivatives 10a-b, respectively. Again compound 3 was reacted with n-butylmagnesium bromide or diazomethane to give the dibutyl derivative 12 or 13.
1,3 - 二苯基 - 4 - 硫酮 - 2,5 - 咪唑啉二酮（3）与氨基化合物和邻二胺反应，分别生成1,3 - 二苯基 - 4 - 取代亚氨基 - 2,5 - 咪唑啉二酮（4a - m）和1,3 - 二苯基 - 1H - 咪唑并[4,5 - b]喹喔啉 - 2(3H) - 酮（5a - c）。3与肼缩合得到相应的腙衍生物（6a - c）。6a与乙酰氯、芳香醛、芳基磺酰氯、邻苯二甲酸酐以及异氰酸酯或硫氰酸酯反应，分别生成乙酰氨基衍生物6b、苄叉亚氨基衍生物7a - d、芳基磺酰胺基衍生物8a - b、邻苯二甲酰亚氨基衍生物9a - b以及脲基和硫脲基衍生物10a - b。此外，化合物3与正丁基溴化镁或重氮甲烷反应，得到二丁基衍生物12或13。
