一系列具有生物学意义的新型6'-氯-1',1'-二氧代螺[4-苯并[][1,3,7]恶二唑啉-4,3'(2')-[1,4,2]苯并二噻嗪]-2,6(1,5)二酮衍生物的合成。

Synthesis of a new series of biologically interesting 6'-chloro-1',1'-dioxospiro[4-benzo[][1,3,7]oxadiazocine-4,3'(2')-[1,4,2]benzodithiazine]-2,6(1,5)dione derivatives.

作者信息

Brzozowski Zdzisław, Żołnowska Beata, Sławiński Jarosław

机构信息

Department of Organic Chemistry, Medical University of Gdańsk, Gen. J. Hallera Str. 107, 80416 Gdańsk, Poland.

出版信息

Monatsh Chem. 2013;144(9):1397-1405. doi: 10.1007/s00706-013-1010-y. Epub 2013 Jun 11.

ABSTRACT

A series of 6'-chloro-1',1'-dioxospiro[4-benzo[][1,3,7]oxadiazocine-4,3'(2')-[1,4,2]benzodithiazine]-2,6(1,5)dione derivatives have been synthesized from isatoic anhydride and 3-(R-amino)-1,4,2-benzodithiazine 1,1-dioxides. Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.