特发性肝内胆汁淤积作为霍奇金淋巴瘤的一种罕见表现
Idiopathic Intrahepatic Cholestasis as an Unusual Presentation of Hodgkin's Disease.
作者信息
Atalay Hande, Boyuk Banu, Ates Muhammet, Celebi Aslan, Ekizoglu Ismail, Didik Arzu A, Igdem Aysenur A
机构信息
Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, 34240 Istanbul, Turkey.
Department of Pathology, Gaziosmanpasa Taksim Education and Research Hospital, 34240 Istanbul, Turkey.
出版信息
Case Rep Hematol. 2015;2015:987860. doi: 10.1155/2015/987860. Epub 2015 Jun 18.
Intrahepatic cholestasis in the form of paraneoplastic phenomena is an uncommon presentation of Hodgkin's lymphoma (HL). Herein we report the diagnosis of mixed type HL-related idiopathic intrahepatic cholestasis in a 73-year-old man presenting with jaundice, after the inguinal lymph node biopsy indicative of mixed cellular type HL and liver biopsy consistent with intrahepatic cholestasis, following several diagnostic interventions including surgery for suspected extrahepatic obstructive cholestasis. Our findings emphasize the value of early liver biopsy in the diagnostic algorithm along with consideration of HL-related idiopathic intrahepatic cholestasis as a diagnosis of exclusion in cholestatic jaundice of obscure origin.
以副肿瘤综合征形式出现的肝内胆汁淤积是霍奇金淋巴瘤（HL）的一种罕见表现。在此，我们报告了一名73岁男性混合细胞型HL相关特发性肝内胆汁淤积的诊断，该患者出现黄疸，腹股沟淋巴结活检提示混合细胞型HL，肝活检符合肝内胆汁淤积，此前进行了包括针对疑似肝外梗阻性胆汁淤积的手术在内的多项诊断性干预措施。我们的研究结果强调了在诊断流程中早期肝活检的价值，同时应将HL相关特发性肝内胆汁淤积视为不明原因胆汁淤积性黄疸的排除性诊断。
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