在一组甲状腺功能正常的老年受试者中，平均血小板体积与促甲状腺激素的血清水平显著相关。

Mean platelet volume is significantly associated with serum levels of thyroid-stimulating hormone in a cohort of older euthyroid subjects.

作者信息

Lippi Giuseppe, Danese Elisa, Montagnana Martina, Nouvenne Antonio, Meschi Tiziana, Borghi Loris

机构信息

a Laboratory of Clinical Chemistry and Hematology , Academic Hospital of Parma , Parma , Italy .

b Clinical Chemistry Section, Department of Life and Reproductive Sciences, Academic Hospital of Verona , Verona , Italy , and.

出版信息

Endocr Res. 2015;40(4):227-30. doi: 10.3109/07435800.2015.1037392. Epub 2015 Jul 13.

DOI:10.3109/07435800.2015.1037392

PMID:26167760

Abstract

PURPOSE

This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects.

MATERIALS AND METHOD

The study population was represented by a cohort of 1,050 ostensibly healthy and euthyroid patients aged 50 years and older, who were referred for screening of thyroid disorders over a 1-year period.

RESULTS

A significant association was found between MPV and TSH values in both simple (r = 0.12; p < 0.001) and multivariable regression analysis (beta coefficient, 0.07; p < 0.001) after adjustment for age, sex, free thyroxin values and platelet count. After stratification of the study population according to quartiles of serum TSH levels, a graded increase of MPV values was found from the first to the fourth quartile of TSH (p = 0.013). The odds ratio for an increased MPV value of the fourth versus the first quartile of TSH was 1.54 (95% CI, 1.08-2.20; p = 0.017).

CONCLUSIONS

The results of this investigation demonstrate that a significant, positive and independent association exists between MPV and serum TSH values in a large cohort of older euthyroid Italian subjects.

摘要

目的

这项回顾性观察研究旨在确定在一大群甲状腺功能正常的老年意大利受试者中，血清促甲状腺激素（TSH）值与平均血小板体积（MPV）值之间是否存在任何关联。

材料与方法

研究人群由1050名表面健康且甲状腺功能正常的50岁及以上患者组成，他们在1年时间内被转诊进行甲状腺疾病筛查。

结果

在对年龄、性别、游离甲状腺素值和血小板计数进行调整后，单因素（r = 0.12；p < 0.001）和多因素回归分析（β系数，0.07；p < 0.001）均发现MPV与TSH值之间存在显著关联。根据血清TSH水平四分位数对研究人群进行分层后，发现从TSH的第一个四分位数到第四个四分位数，MPV值呈分级增加（p = 0.013）。TSH第四个四分位数与第一个四分位数相比，MPV值增加的优势比为1.54（95%CI，1.08 - 2.20；p = 0.017）。