脉冲射频治疗颈2-3后内侧支治疗慢性偏头痛的疗效：一项随机、对照、双盲试验
Efficacy of Pulsed Radiofrequency on Cervical 2-3 Posterior Medial Branches in Treating Chronic Migraine: A Randomized, Controlled, and Double-Blind Trial.
作者信息
Yang Yuecheng, Huang Xuehua, Fan Yinghui, Wang Yingwei, Ma Ke
机构信息
Pain Management Center and Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China.
出版信息
Evid Based Complement Alternat Med. 2015;2015:690856. doi: 10.1155/2015/690856. Epub 2015 Jun 11.
Objective. The aim of this study was to examine the efficacy and safety of pulsed radiofrequency (PRF) in the treatment of chronic migraine (CM) on cervical 2-3 posterior medial branches. Methods. This randomized, double-blind, and controlled clinical trial included 40 subjects with CM, who were randomly divided into two groups: treatment (treated by PRF) and sham (treated by sham treatment). Pain intensity, headache duration (days), the Migraine Disability Assessment Questionnaire (MIDAS), and aspirin dose taken by patients were evaluated at 1, 2, and 6 months after the intervention. Side effects were observed from the time of treatment and throughout the follow-up period. Results. During the follow-up, pain intensity, headache duration (days), disability score, and the analgesic dose were significantly improved in the treatment group compared to the sham group (P < 0.001) and the baseline (P < 0.001) at all measured time points after intervention. No serious complications were reported. Conclusion. PRF on the cervical 2-3 posterior medial branches could provide satisfactory efficacy in the treatment of CM without obvious adverse effects.
目的。本研究旨在探讨脉冲射频（PRF）治疗颈2 - 3后内侧支慢性偏头痛（CM）的疗效和安全性。方法。这项随机、双盲、对照临床试验纳入了40例CM患者，随机分为两组：治疗组（接受PRF治疗）和假手术组（接受假治疗）。在干预后1个月、2个月和6个月评估疼痛强度、头痛持续时间（天数）、偏头痛残疾评估问卷（MIDAS）以及患者服用阿司匹林的剂量。从治疗时起直至整个随访期观察副作用。结果。随访期间，与假手术组相比，治疗组在干预后的所有测量时间点，疼痛强度、头痛持续时间（天数）、残疾评分和镇痛剂量均有显著改善（P < 0.001），与基线相比也有显著改善（P < 0.001）。未报告严重并发症。结论。颈2 - 3后内侧支的PRF治疗CM疗效满意，且无明显不良反应。
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