Hilton N Zoe, Ham Elke, Lang Carol, Harris Grant T
Associate Professor, Department of Psychiatry, University of Toronto, Toronto, Ontario; Senior Research Scientist, Waypoint Research Institute, Penetanguishene, Ontario.
Research Psychometrist, Waypoint Research Institute, Penetanguishene, Ontario.
Can J Psychiatry. 2015 May;60(5):232-8. doi: 10.1177/070674371506000505.
We investigated changes in weight, body mass index (BMI), and other indices of the metabolic syndrome in forensic inpatients. Weight gain associated with newer antipsychotics (APs) is well established in the general psychiatric population.
We examined the medical records of 291 men admitted to a forensic hospital at admission and again at discharge or 365 days later if still in hospital. We also recorded diagnosis and smoker status on admission and quantified psychotropic treatment and adherence, physical activity, and daytime occupation during the hospitalization.
On admission, 33% were obese and 22% of the 106 patients for whom sufficient data were available met criteria for metabolic syndrome. Among patients staying at least 30 days, 60% were weighed again before discharge but repeated blood pressure and waist circumference measures were uncommon, even among those at greatest risk. The 122 forensic inpatients with sufficient information gained an average of 12% of their body weight and 40% increased by at least 1 BMI category, gaining an average of 3.67 kg per month. Weight gain was associated with duration of time and was not attributable to being underweight on admission, diagnosis of schizophrenia, atypical AP treatment, medication adherence, or having been a smoker.
Patients gained weight during forensic hospitalization independent of medication use. We recommend further research using consistent measurement and wider sampling of both metabolic syndrome indicators and its individual and systemic causes in forensic populations.
我们调查了法医住院患者的体重、体重指数(BMI)及代谢综合征其他指标的变化。新型抗精神病药物(APs)导致体重增加在普通精神科人群中已得到充分证实。
我们查阅了291名男性法医住院患者入院时及出院时(若仍住院则为365天后)的病历。我们还记录了入院时的诊断和吸烟状况,并对住院期间的精神药物治疗及依从性、身体活动和日间职业进行了量化。
入院时,33%的患者肥胖,在有足够数据的106名患者中,22%符合代谢综合征标准。在住院至少30天的患者中,60%在出院前再次称重,但重复测量血压和腰围的情况并不常见,即使是在风险最高的患者中也是如此。122名有足够信息的法医住院患者平均体重增加了12%,40%的患者BMI至少上升了一个类别,平均每月增加3.67千克。体重增加与住院时间有关,与入院时体重过轻、精神分裂症诊断、非典型抗精神病药物治疗、药物依从性或吸烟无关。
法医住院患者体重增加与药物使用无关。我们建议开展进一步研究,在法医人群中对代谢综合征指标及其个体和系统性病因进行一致的测量和更广泛的抽样。