Yamasaki Fumiyuki, Takayasu Takeshi, Nosaka Ryo, Vishwa Amatya Jeet, Takeshima Yukio, Yoshihiro Masako, Kurisu Kaoru
Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Childs Nerv Syst. 2016 Jan;32(1):189-93. doi: 10.1007/s00381-015-2822-3. Epub 2015 Jul 15.
We report a very rare case of a fast-growing benign fibrous histiocytoma at the temporal bone.
A 1-year-old girl was referred for investigation of a right temporal mass that increased during 2-week observation. Imaging studies showed a lytic, loculated skull tumor at the left temporal bone. On magnetic resonance imaging scans, the tumor was isointense on T1- and relatively high-intense on T2-weighted images. The tumor was mostly homogeneously enhanced by gadolinium. On diffusion-weighted images, it was iso- to relatively low-intense; perfusion-weighted images revealed low perfusion.
Complete macroscopic resection of the tumor was performed. Immunohistochemical analysis showed that the tumor was positive for CD68 and α-smooth muscle actin and negative for CD1a and CD34; the MIB-1 labeling index was 4 %. A diagnosis of primary benign fibrous histiocytoma of the skull was made. At 6-month follow-up, there were no clinical or radiological signs of tumor recurrence and/or metastasis.
We review the clinical, radiological, and immunohistochemical characteristics of benign fibrous histiocytoma at the skull.
我们报告一例非常罕见的颞骨快速生长的良性纤维组织细胞瘤病例。
一名1岁女孩因右颞部肿块前来就诊，该肿块在2周的观察期内增大。影像学检查显示左侧颞骨有一个溶骨性、分叶状颅骨肿瘤。在磁共振成像扫描中，肿瘤在T1加权像上呈等信号，在T2加权像上呈相对高信号。肿瘤大部分被钆均匀强化。在扩散加权像上，它呈等信号至相对低信号；灌注加权像显示灌注低。
对肿瘤进行了完整的肉眼切除。免疫组织化学分析显示肿瘤CD68和α-平滑肌肌动蛋白呈阳性，CD1a和CD34呈阴性；MIB-1标记指数为4%。诊断为原发性颅骨良性纤维组织细胞瘤。在6个月的随访中，没有肿瘤复发和/或转移的临床或放射学迹象。
我们回顾了颅骨良性纤维组织细胞瘤的临床、放射学和免疫组织化学特征。
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