Wei Wen, Lv Min, Zhang Jian, Hua Shan, Shang Qi-Yun
Department of Respiratory Medicine, Anhui Provincial Children's Hospital, Hefei 230051, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jul;17(7):702-5.
To investigate the characteristics of pulmonary function in children with atypical asthma with chest tightness as the chief complaint before and after a bronchial provocation test.
This study included 34 children with atypical asthmas who underwent bronchial provocation test between January 2010 and December 2013. Thirty-four children with typical asthmas were selected as the control group. The pulmonary function of the atypical asthma group was examined before and after the bronchial provocation test and compared with that of the control group in the acute episode and remission stages.
The forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, peak expiratory flow, forced expiratory flow 25%, 50%, 75% (FEF25, FEF50, FEF75), and maximum mid-expiratory flow (MMEF75/25) in the atypical asthma group before the bronchial provocation test were (105±12)%, (104±12)%, (100±7)%, (88±13)%, (90±14)%, (81±17)%, (73±25)%, and (80±17)%, respectively; these functional indices were significantly higher than in the control group in the acute episode stage (P<0.05), but were similar to those of the control group in the remission stage (P>0.05). In addition, no significant difference in pulmonary indices was observed between the atypical asthma group after the bronchial provocation test and the control group in the acute episode stage (P>0.05), but functional indices above were significantly lower in the atypical asthma group after the bronchial provocation test than in the control group in the remission stage and the atypical asthma group before the bronchial provocation test (P<0.05).
Bronchial provocation test is useful in the diagnosis of atypical asthma in children.
探讨以胸闷为主要症状的非典型哮喘患儿支气管激发试验前后的肺功能特点。
本研究纳入了2010年1月至2013年12月期间接受支气管激发试验的34例非典型哮喘患儿。选取34例典型哮喘患儿作为对照组。对非典型哮喘组患儿在支气管激发试验前后进行肺功能检查，并与对照组在急性发作期和缓解期的肺功能进行比较。
非典型哮喘组患儿在支气管激发试验前的用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC、呼气峰值流速、25%、50%、75%用力呼气流量（FEF25、FEF50、FEF75）以及最大呼气中期流速（MMEF75/25）分别为（105±12）%、（104±12）%、（100±7）%、（88±13）%、（90±14）%、（81±17）%、（73±25）%和（80±17）%；这些功能指标在急性发作期显著高于对照组（P<0.05），但在缓解期与对照组相似（P>0.05）。此外，支气管激发试验后非典型哮喘组与对照组在急性发作期的肺功能指标无显著差异（P>0.05），但支气管激发试验后非典型哮喘组上述功能指标显著低于对照组在缓解期以及非典型哮喘组在支气管激发试验前（P<0.05）。
支气管激发试验对儿童非典型哮喘的诊断有帮助。
Zotero 插件