儿童急性髓系白血病的家族史与复发

Family History and Relapse in Pediatric Acute Myeloid Leukemia.

作者信息

Mehrvar Azim, Tashvighi Maryam, Faranoush Mohammad, Reinhardt Dirk, Niktoreh Mofrad Naghmeh, Hedayati Asl Amir Abbas, Alebouyeh Mardawij

机构信息

Mahak's Pediatric Cancer Treatment and Research Center, Army Medical Science University, Tehran, Iran.

Mahak's Pediatric Cancer Treatment and Research Center, Islamic Azad University of Qom, Qom, Iran.

出版信息

Pediatr Blood Cancer. 2015 Dec;62(12):2235-7. doi: 10.1002/pbc.25649. Epub 2015 Jul 16.

DOI:10.1002/pbc.25649

PMID:26184891

Abstract

We report the epidemiology and characteristics of acute myeloid leukemia and outcomes of its treatment with the AML-BFM 83 protocol at the Mahak Pediatric Cancer Treatment and Research Center, Tehran, Iran, from 2007 to 2012. A positive family history of cancer or leukemia was associated with the risk of relapse (family history of cancer in relapse: n = 11; 61%, P = 0.136, leukemia: n = 7; 39%; P = 0.016). Treatment-related mortality was 19% and associated with underweight patients (n = 5; 62.5%; P = 0.158). Event-free and overall survivals were 36% (SE = 3.5) and 44% (SE = 3.4), respectively. These data suggest a possible relationship between family history and relapse rate.

摘要

我们报告了2007年至2012年期间，伊朗德黑兰马哈克儿童癌症治疗与研究中心急性髓系白血病的流行病学、特征以及采用AML-BFM 83方案治疗的结果。癌症或白血病的阳性家族史与复发风险相关（复发时有癌症家族史：n = 11；61%，P = 0.136，白血病家族史：n = 7；39%；P = 0.016）。治疗相关死亡率为19%，且与体重不足的患者相关（n = 5；62.5%；P = 0.158）。无事件生存率和总生存率分别为36%（标准误 = 3.5）和44%（标准误 = 3.4）。这些数据表明家族史与复发率之间可能存在关联。