深度低温治疗难治性癫痫持续状态。
Deep hypothermia for the treatment of refractory status epilepticus.
作者信息
Niquet Jerome, Baldwin Roger, Gezalian Michael, Wasterlain Claude G
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
出版信息
Epilepsy Behav. 2015 Aug;49:313-7. doi: 10.1016/j.yebeh.2015.06.028. Epub 2015 Jul 18.
Abstract
In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE. This article is part of a Special Issue entitled "Status Epilepticus".
摘要
在由锂盐和毛果芸香碱诱导且对咪达唑仑难治的癫痫持续状态（SE）大鼠模型中，深度低温（20℃持续30分钟）使脑电图功率降低50倍以上，在12分钟内终止了SE，并使脑电图棘波减少了87%。低温作为难治性SE的最后治疗手段值得进一步研究。本文是名为“癫痫持续状态”的特刊的一部分。
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