Hayata Thaís T, Bergo Felipe P G, Rezende Thiago J, Damasceno Alfredo, Damasceno Benito P, Cendes Fernando, Stella Florindo, Balthazar Marcio L F
Laboratório de Neuroimagem, Departamento de Neurologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brazil.
Arq Neuropsiquiatr. 2015 Jul;73(7):553-60. doi: 10.1590/0004-282X20150068.
Neuropsychiatric symptoms in Alzheimer's disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives To compare cortical atrophy's patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 controls underwent a 3T MRI scanning. We considered four NPI syndromes: affective, apathy, hyperactivity and psychosis. Correlations between structural imaging and neuropsychiatric scores were performed by Freesurfer. Results were significant with a p-value < 0.05, corrected for multiple comparisons. Results Patients exhibited atrophy in entorhinal cortices, left inferior and middle temporal gyri, and precuneus bilaterally. There was correlation between affective syndrome and cortical thickness in right frontal structures, insula and temporal pole. Conclusion Cortical thickness measures revealed atrophy in mild AD. Depression and anxiety symptoms were associated with atrophy of right frontal, temporal and insular cortices.
阿尔茨海默病（AD）中的神经精神症状很常见，但其与皮质萎缩模式之间的关系尚不完全清楚。目的：比较AD患者与健康对照者的皮质萎缩模式；验证神经精神综合征与皮质萎缩之间的相关性。方法：采用神经精神科问卷（NPI）对33例AD患者进行检查。患者和29名对照者接受了3T磁共振成像扫描。我们考虑了四种NPI综合征：情感症状、淡漠、多动和精神病性症状。通过Freesurfer软件进行结构成像与神经精神评分之间的相关性分析。结果在进行多重比较校正后，p值<0.05时结果具有显著性。结果：患者双侧内嗅皮质、左侧颞下回和颞中回以及楔前叶出现萎缩。情感综合征与右侧额叶结构、岛叶和颞极的皮质厚度之间存在相关性。结论：皮质厚度测量显示轻度AD存在萎缩。抑郁和焦虑症状与右侧额叶、颞叶和岛叶皮质萎缩有关。
