Oliveira Francine Hehn de, Rodrigues Neto Edson, Fonseca Mariana Kumaira, Costa André Silvestre Reitz da, Rockenbach Marcio Aloisio Bezerra Cavalcanti, Padilha Renata dos Santos, Fernandez Liana Lisboa, Hilbig Arlete
Departamento de Patologia, Faculdade de Medicina, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Arq Neuropsiquiatr. 2015 Jul;73(7):569-77. doi: 10.1590/0004-282X20150066.
With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases by years. The tau protein is particularly interesting: it might be found in the brainstem and olfactory bulb long before it reaches the limbic cortex, at which point symptoms occur. Of the 14 brains collected in this study, the tau protein was found in the brainstems of 10 (71.42%) and in olfactory bulbs of 3 out 11. Of the 7 individuals who had a final diagnosis of Alzheimer's disease (AD), 6 presented tau deposits in some region of the brainstem. Our data support the idea of the presence of tau protein in the brainstem and olfactory bulb in the earliest stages of AD.
随着巴西人均寿命的增加，人们对老年人中最普遍的疾病越来越担忧。这些疾病包括神经退行性疾病，如阿尔茨海默病和帕金森病。与这些疾病发展相关的蛋白质沉积物可能在症状出现阶段的数年前就已存在。tau蛋白尤其引人关注：在其到达边缘皮质（此时症状出现）之前很久，就可能在脑干和嗅球中被发现。在本研究收集的14个大脑中，10个（71.42%）的脑干中发现了tau蛋白，11个中有3个的嗅球中发现了tau蛋白。在最终诊断为阿尔茨海默病（AD）的7名个体中，6名在脑干的某些区域出现了tau沉积物。我们的数据支持了在AD的最早阶段脑干和嗅球中存在tau蛋白这一观点。
