Sucato Vincenzo, Evola Salvatore, Novo Giuseppina, Sansone Angela, Quagliana Angelo, Andolina Giuseppe, Assennato Pasquale, Novo Salvatore
Division of Cardiology, Biomedical Department of Internal Medicine and Specialties (DiBiMIS), Paolo Giaccone Hospital, University of Palermo, Palermo, Italy.
Microcirculation. 2015 Oct;22(7):528-33. doi: 10.1111/micc.12223.
The aim of this study was to evaluate myocardial perfusion and coronary blood flow through validated angiography indices to assess whether there is greater MVD in patients with microvascular angina and HFPEF compared to those who do not have.
Our study was performed on a population of 286 patients with stable angina that underwent coronary angiography and echocardiography. They showed epicardial coronary arteries free from stenosis. We divided the sample into two categories: patients with HFPEF and those without. We calculated indices for each patient based on angiographic images, including TFC, MBG, and TMBS.
Our sample compared two groups: HFPEF (n = 155) and non-HFPEF (n = 135) patients. We showed that patients with HFPEF had a longest TFC of three major coronary arteries (TFC LAD 44.7 ± 12.5; TFC RCA 26.2 ± 6.9; TFC CX 27 ± 5.9) than non-HFPEF patients (TFC LAD 40.7 ± 11.6; TFC RCA 25 ± 6.3; TFC CX 21 ± 4.7). On the other hand, we found lower MBG on three coronary arteries (MBG LAD 2.1 ± 0.3; MBG RCA 2.1 ± 0.3; MBG CX 2.0 ± 0.32) in HFPEF than non-HFPEF patients (MBG LAD 2.6 ± 0.5; MBG RCA 2.2 ± 0.47; MBG CX 2.3 ± 0.4).
Analysis of microcirculation through angiography indices in patients with and without HFPEF has led to assess that the HFPEF population has a greater involvement of microcirculation than patients without HFPEF.
本研究旨在通过经过验证的血管造影指标评估心肌灌注和冠状动脉血流，以评估微血管性心绞痛和射血分数保留的心力衰竭（HFpEF）患者与无这些疾病的患者相比是否存在更严重的微血管功能障碍（MVD）。
我们对286例接受冠状动脉造影和超声心动图检查的稳定型心绞痛患者进行了研究。他们的冠状动脉造影显示无狭窄。我们将样本分为两类：HFpEF患者和非HFpEF患者。我们根据血管造影图像为每位患者计算指标，包括心肌血流储备分数（TFC）、心肌 blush分级（MBG）和心肌血流储备分数斜率（TMBS）。
我们的样本比较了两组：HFpEF患者（n = 155）和非HFpEF患者（n = 135）。我们发现，HFpEF患者三大冠状动脉的TFC最长（左前降支TFC 44.7±12.5；右冠状动脉TFC 26.2±6.9；回旋支TFC 27±;5.9），高于非HFpEF患者（左前降支TFC 40.7±11.6；右冠状动脉TFC 25±6.3；回旋支TFC 21±4.7）。另一方面，我们发现HFpEF患者三大冠状动脉的MBG低于非HFpEF患者（左前降支MBG 2.1±0.3；右冠状动脉MBG 2.1±0.3；回旋支MBG 2.0±0.32）（左前降支MBG 2.6±0.5；右冠状动脉MBG 2.2±0.47；回旋支MBG 2.3±0.4）。
通过血管造影指标分析有无HFpEF患者的微循环，结果表明HFpEF患者的微循环受累程度高于非HFpEF患者。
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