氟化烯醇硅醚与色胺酮的高效无催化剂 Mukaiyama-羟醛反应

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin.

作者信息

Liao Fu-Min, Liu Yun-Lin, Yu Jin-Sheng, Zhou Feng, Zhou Jian

机构信息

Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China.

出版信息

Org Biomol Chem. 2015 Sep 7;13(33):8906-11. doi: 10.1039/c5ob01125f.

DOI:10.1039/c5ob01125f

PMID:26205007

Abstract

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

摘要

我们报道了色胺酮与氟化烯醇硅醚的高效 Mukaiyama-羟醛反应，该反应在甲醇中进行，无需使用任何催化剂。此方法应用于天然产物 Phaitanthrin B 的二氟类似物的全合成。