Wang Yan, Zhou Junlin, Yan Fen, Li Gong, Duan Xiaofen, Pan Heng, He Jiao
Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Beijing Feng-Tai Hospital, Capital Medical University, Beijing, China (mainland).
Med Sci Monit. 2015 Jul 24;21:2141-8. doi: 10.12659/MSM.893677.
Gross deformity of the foot in Charcot neuroarthropathy can lead to foot collapse and subsequent ulceration, infection, amputation, or premature death. Total-contact casting (TCC) is a well-established treatment for neuropathic diabetic plantar foot ulcers. It was hypothesized that arthrodesis plus TCC may have advantages over TCC alone. This pilot study compared the effectiveness of arthrodesis plus TCC with TCC alone for the prevention, treatment, and recurrence of midfoot ulcerations associated with Charcot neuroarthropathy.
Twenty-one subjects with plantar ulcers associated with unilateral diabetic Charcot midfoot neuroarthropathy were randomly assigned to ADS or TCC groups. The ADS group underwent an extended medial column arthrodesis procedure and TCC; ulcers were sutured directly. The TCC group underwent TCC alone with dressing changes. All patients underwent nerve conduction studies and quantitative sensory testing at baseline and during follow-up (6 and 12 months). Healing time and ulcer relapse rate were evaluated.
Compared with the TCC group, there were fewer lesions in the ADS group after treatment (P<0.05). Temperature testing and vibration perception threshold improved significantly after ADS (P<0.05). Although the number of patients positive for pinprick and light touch sensations increased after surgery, not all patients recovered these sensations. Healing time was not significantly different between the 2 groups (24.25±3.89 vs. 25.89±2.84 days, P>0.05). There was no ulcer recurrence after 12 months in the ADS group compared with 33.3% in the TCC group.
An extended medial column arthrodesis may partly improve sensory impairments and restore protective sensation in patients with Charcot neuroarthropathy.
夏科氏神经关节病导致的足部严重畸形可致使足部塌陷,进而引发溃疡、感染、截肢或过早死亡。全接触石膏固定(TCC)是治疗神经性糖尿病足底溃疡的一种成熟疗法。据推测,关节融合术联合TCC可能比单纯使用TCC更具优势。这项初步研究比较了关节融合术联合TCC与单纯TCC在预防、治疗和复发性中足溃疡方面的有效性,这些溃疡与夏科氏神经关节病相关。
21例患有单侧糖尿病夏科氏中足神经关节病相关足底溃疡的受试者被随机分配至关节融合术联合石膏固定(ADS)组或TCC组。ADS组接受了内侧柱延长关节融合术及TCC治疗;溃疡直接缝合。TCC组仅接受TCC治疗及换药。所有患者在基线及随访期间(6个月和12个月)均接受神经传导研究和定量感觉测试。评估愈合时间和溃疡复发率。
与TCC组相比,ADS组治疗后病变较少(P<0.05)。ADS治疗后温度测试和振动感觉阈值显著改善(P<0.05)。尽管手术后针刺觉和轻触觉阳性的患者数量增加,但并非所有患者都恢复了这些感觉。两组愈合时间无显著差异(24.25±3.89天对25.89±2.84天,P>0.05)。ADS组12个月后无溃疡复发,而TCC组为33.3%。
内侧柱延长关节融合术可能部分改善夏科氏神经关节病患者的感觉障碍并恢复保护性感觉。