Pr-SNTX是一种来自巴布亚侏儒穆尔加蛇的短链三指毒素，是肌肉型烟碱乙酰胆碱受体（α2βδε）的拮抗剂。
Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε).
作者信息
Yamauchi Yoko, Kimoto Hikari, Yang Xianyu, Filkin Sergey, Utkin Yuri, Kubo Tai, Inagaki Hidetoshi
机构信息
a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan.
b College of Animal Science and Biotechnology , Zhejiang A & F University , Lin'An , China.
出版信息
Biosci Biotechnol Biochem. 2016;80(1):158-61. doi: 10.1080/09168451.2015.1065169. Epub 2015 Jul 25.
Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr-SNTX, from Pseudechis rossignolii. The amino acid sequence of Pr-SNTX is nearly identical to that of its ortholog in Pseudechis australis. Pr-SNTX protein inhibited muscle-type (α2βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity.
三指毒素（3FTxs）是蛇毒的主要成分之一。在本研究中，我们从罗氏拟眼镜蛇（Pseudechis rossignolii）中分离出一个编码短链3FTx（Pr-SNTX）的cDNA。Pr-SNTX的氨基酸序列与其在澳大利亚拟眼镜蛇（Pseudechis australis）中的直系同源物几乎相同。Pr-SNTX蛋白抑制肌肉型（α2βδε）而非神经元α7烟碱型乙酰胆碱受体（nAChR）的活性。
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