壳聚糖和壳寡糖的表征及生物活性研究进展。
Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides.
作者信息
Zou Pan, Yang Xin, Wang Jing, Li Yongfei, Yu Hailong, Zhang Yanxin, Liu Guangyang
机构信息
Department of Food Science and Engineering, School of Chemical Engineering & Technology, Harbin Institute of Technology, No. 73 Huanghe Road, Nangang District, Harbin, Heilongjiang Province 150090, PR China; Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standard & Testing Technology for Agro-Product, Chinese Academy of Agricultural Sciences, No. 12 South Street, Zhongguancun, Haidian District, Beijing 100081, PR China.
Department of Food Science and Engineering, School of Chemical Engineering & Technology, Harbin Institute of Technology, No. 73 Huanghe Road, Nangang District, Harbin, Heilongjiang Province 150090, PR China; Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standard & Testing Technology for Agro-Product, Chinese Academy of Agricultural Sciences, No. 12 South Street, Zhongguancun, Haidian District, Beijing 100081, PR China; Key Laboratory of Agrifood Safety and Quality, Ministry of Agriculture, No. 12 Zhongguancun South Street, Haidian District, Beijing 100081, PR China.
出版信息
Food Chem. 2016 Jan 1;190:1174-1181. doi: 10.1016/j.foodchem.2015.06.076. Epub 2015 Jun 23.
Chitosan and chitosan oligosaccharides (COS) have been reported to possess various biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti-tumour activities. COS have attracted considerable interest due to their physicochemical properties, and potential applications in the food and pharmaceutical industries, especially in cancer therapies. This paper describes the preparation of COS and their physicochemical properties, and modification, which aids understanding of their biological activities. Based on the latest reports, several biological and anti-tumour activities of COS will be discussed. The proposed anti-tumour mechanisms of COS are summarised, to provide comprehensive insights into research on the molecular level. Finally, the potential applications and future development of the biopolymer will be discussed.
据报道，壳聚糖和壳寡糖（COS）具有多种生物医学特性，包括抗菌活性、免疫增强作用和抗肿瘤活性。COS因其物理化学性质以及在食品和制药行业，特别是癌症治疗中的潜在应用而备受关注。本文描述了COS的制备及其物理化学性质和改性，这有助于理解它们的生物活性。基于最新报道，将讨论COS的几种生物学和抗肿瘤活性。总结了COS的抗肿瘤机制，以便在分子水平上提供对研究的全面见解。最后，将讨论这种生物聚合物的潜在应用和未来发展。
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