用于药物递送的非晶态金属有机框架材料。
Amorphous metal-organic frameworks for drug delivery.
作者信息
Orellana-Tavra Claudia, Baxter Emma F, Tian Tian, Bennett Thomas D, Slater Nigel K H, Cheetham Anthony K, Fairen-Jimenez David
机构信息
Department of Chemical Engineering & Biotechnology, University of Cambridge, CB2 3RA Cambridge, UK.
出版信息
Chem Commun (Camb). 2015 Sep 21;51(73):13878-81. doi: 10.1039/c5cc05237h.
PMID:26213904
Abstract
We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.
摘要
我们报道了将亲水性模型分子钙黄绿素封装在锆基金属有机框架材料UiO-66中，随后通过球磨使框架材料非晶化。我们展示了钙黄绿素在超过30天的时间内实现可控释放，相比之下，结晶态的UiO-66的释放期为2天。
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