MMP-9 触发胶束到纤维的转变，实现阿霉素的缓慢释放。
MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin.
机构信息
West CHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
出版信息
Biomater Sci. 2015 Feb;3(2):246-9. doi: 10.1039/c4bm00297k. Epub 2014 Oct 28.
PMID:26218115
Abstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
摘要
苯乙酰肽两亲物被设计出来，在与疾病相关的酶的作用下发生切割，它们从胶束聚集物重新构成纤维。在这种形态变化之后，阿霉素的有效载荷可以保留在形成的纤维中，这使它们成为局部形成纳米纤维库的有价值载体，用于疏水性抗癌药物的缓慢释放。
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