神经内分泌细胞分化在人胃癌中的预后作用。
Prognostic role of neuroendocrine cell differentiation in human gastric carcinoma.
作者信息
Zhang Tingting, Su Dan, Mao Zhiyuan, Guo Xiaochuan, Wang Lijie, Bai Li
机构信息
Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
出版信息
Int J Clin Exp Med. 2015 May 15;8(5):7837-42. eCollection 2015.
The objective of the current study was to investigate the significance and biologic characteristic of neuroendocrine cell differentiation (NED) in gastric carcinoma by comparing the prognosis and clinicopathologic characteristics between patients with or without NED. Retrospective analyses of neuroendocrine markers, neuron specific enolase (NSE), chromogranin A (CgA), and synaptophysin (Syn) were performed in 174 human gastric carcinoma patients. NED association was found in 21.3% gastric carcinoma patients, with or without NED, and was correlated with tumor location, cancer emboli, infiltrative depth, TNM stage and distant metastasis (P < 0.05 in each case). The 1-year and 3-year survival rate of the patients who suffered from gastric carcinoma with NED were significantly lower than those without NED. The overall survival time of patients with NED was shorter than those with gastric carcinoma without NED, with a significant difference between the two types (P = 0.037). Cumulatively, gastric carcinoma patients with NED had shorter postoperative survival time and poorer prognosis.
本研究的目的是通过比较有或没有神经内分泌细胞分化（NED）的胃癌患者的预后和临床病理特征，探讨NED在胃癌中的意义和生物学特性。对174例人类胃癌患者进行了神经内分泌标志物神经元特异性烯醇化酶（NSE）、嗜铬粒蛋白A（CgA）和突触素（Syn）的回顾性分析。在21.3%的胃癌患者中发现了NED关联，无论有无NED，其均与肿瘤位置、癌栓、浸润深度、TNM分期和远处转移相关（每种情况P<0.05）。患有NED的胃癌患者的1年和3年生存率显著低于没有NED的患者。NED患者的总生存时间短于没有NED的胃癌患者，两种类型之间存在显著差异（P=0.037）。总体而言，患有NED的胃癌患者术后生存时间较短，预后较差。
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