类固醇受体相关亲免素：通往类固醇信号传导的门户
Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.
作者信息
Ratajczak Thomas, Cluning Carmel, Ward Bryan K
机构信息
Laboratory for Molecular Endocrinology, Harry Perkins Institute of Medical Research and the UWA Centre for Medical Research, The University of Western Australia, Nedlands WA 6009, Australia; ; Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands WA 6009, Australia.
出版信息
Clin Biochem Rev. 2015 May;36(2):31-52.
The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner. Aberrant expression of these functionally unique immunophilins has the potential to cause steroid-based diseases, including breast and prostate cancer, diabetes and related metabolic disorders, male and female infertility and major depressive disorders. This review addresses the function of these proteins as co-chaperones in steroid receptor-Hsp90 complexes and extensively covers current knowledge of the link between the steroid receptor-associated immunophilins and human disease. An improved understanding of their mechanisms of action has revealed opportunities for molecular therapies to enhance or inhibit cellular processes under immunophilin control that contribute both to human health and disease.
类固醇受体相关亲免素FKBP51、FKBP52、CyP40和PP5在类固醇受体功能中具有特定作用，它们以组织特异性方式影响类固醇激素结合亲和力、核质穿梭以及靶基因的转录激活。这些功能独特的亲免素异常表达有可能引发基于类固醇的疾病，包括乳腺癌和前列腺癌、糖尿病及相关代谢紊乱、男性和女性不育症以及重度抑郁症。本综述阐述了这些蛋白质作为类固醇受体 - Hsp90复合物中共伴侣的功能，并广泛涵盖了目前关于类固醇受体相关亲免素与人类疾病之间联系的知识。对其作用机制的深入了解揭示了分子疗法的机会，以增强或抑制亲免素控制下的细胞过程，这些过程对人类健康和疾病都有影响。
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