大鼠联合暴露于2,5-己二酮与丙酮或乙醇的神经生理和行为效应
Neurophysiological and behavioural effects of combined exposure to 2,5-hexanedione and acetone or ethanol in rats.
作者信息
Ladefoged O, Hass U, Simonsen L
机构信息
Department of Toxicology and Biology, Danish National Institute of Occupational Health, Copenhagen.
出版信息
Pharmacol Toxicol. 1989 Nov;65(5):372-5. doi: 10.1111/j.1600-0773.1989.tb01191.x.
Rats were dosed with 2,5-hexanedione (2,5-HD), acetone, ethanol or combinations of these for 6 weeks. Nerve conduction velocity (NCV) was measured in the tails of the rats once a week from the third week of dosing. Behaviour was monitored during the whole experiment as performance on a rotarod, in 30 sec. sessions. 2,5-HD alone showed a significant effect on NCV and rotarod performance after 3 weeks of dosing. Acetone, but not ethanol, together with 2,5-HD had an additional significant effect on NCV and rotarod performance of the rats. This additional effect was seen from the 4th dosage week. The mechanism behind this effect is partly unknown.
给大鼠分别用2,5 -己二酮（2,5 - HD）、丙酮、乙醇或它们的组合进行给药，持续6周。从给药第3周起，每周测量一次大鼠尾巴的神经传导速度（NCV）。在整个实验过程中，以大鼠在转棒上30秒时间段内的表现来监测其行为。单独使用2,5 - HD给药3周后，对NCV和转棒表现有显著影响。丙酮（而非乙醇）与2,5 - HD共同给药时，对大鼠的NCV和转棒表现有额外的显著影响。这种额外影响从第4个给药周开始显现。这种影响背后的机制部分尚不清楚。
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