从口到肛门：果蝇肠道中肠神经元的功能和结构相关性

From mouth to anus: Functional and structural relevance of enteric neurons in the Drosophila melanogaster gut.

作者信息

Kuraishi Takayuki, Kenmoku Hiroyuki, Kurata Shoichiro

机构信息

Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; PRESTO, Japan Science and Technology Agency, Tokyo, Japan.

Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

出版信息

Insect Biochem Mol Biol. 2015 Dec;67:21-6. doi: 10.1016/j.ibmb.2015.07.003. Epub 2015 Jul 29.

DOI:10.1016/j.ibmb.2015.07.003

PMID:26232723

Abstract

The intestinal tract is the main organ involved in host nutritional homeostasis. Intestinal function in both vertebrates and invertebrates is partly controlled by enteric neurons that innervate the gut. Though anatomical and functional aspects of enteric neurons are relatively less characterized in Drosophila than in large insects, analyses of the role of the enteric neurons in flies have remarkably progressed in the last few years. In this review, we first provide a summary of the structure and function of the Drosophila intestine. We then discuss recent studies of the structure and function of enteric neurons in Drosophila melanogaster.

摘要

肠道是参与宿主营养稳态的主要器官。脊椎动物和无脊椎动物的肠道功能部分受支配肠道的肠神经元控制。尽管与大型昆虫相比，果蝇肠神经元的解剖学和功能方面的特征相对较少，但在过去几年中，对果蝇中肠神经元作用的分析有了显著进展。在这篇综述中，我们首先总结了果蝇肠道的结构和功能。然后讨论了黑腹果蝇肠神经元结构和功能的最新研究。