Galicia-Tornell Myriam, Reyes-López Alfonso, Ruíz-González Sergio, Bolio-Cerdán Alejandro, González-Ojeda Alejandro, Fuentes-Orozco Clotilde
Departamento de Cirugía Cardiotorácica Pediátrica, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Departamento de Cirugía Cardiovascular, Hospital Infantil de México Federico Gómez, México, D.F., México.
Cir Cir. 2015 Nov-Dec;83(6):478-84. doi: 10.1016/j.circir.2015.06.003. Epub 2015 Jul 29.
Primary repair of Fallot tetralogy has been performed successfully for the last 45 years. It has low surgical mortality (< 5%), with excellent long-term results. However, there are delayed adverse effects: progressive right ventricular dilation and dysfunction, arrhythmia, and sudden death. In our centre, Fallot tetralogy is the most common form of cyanotic congenital heart disease (including transannular patch) and accounts for 7.5% of all cardiovascular surgical procedures. The mid-term follow-up results are reported.
Case series. The study included patients who had complete repair of Fallot tetralogy with transannular patch from January 2000 to December 2009. An analysis was performed on the clinical variables, morbidity and mortality.
There were 52 patients in the study, with mean age 4 ± 2 years. Perioperative mortality in 6 patients, with 5 associated with residual right ventricular obstruction and, 1 associated with further surgery. The survival rate was 88% (46) patients, with a follow-up 75 ± 26 months. Late morbidity occurred in 14, due to right ventricular dysfunction in 11, recurrent distal obstruction in 2, and residual ventricular septal defect in 1. Associated risk factors were severe pulmonary insufficiency (p=0.001); QRS > 160 ms, p=0.001); cardiothoracic > 0.60 index, (p=0.048), and tricuspid regurgitation (p=0.001).
There was reasonable long-term survival and excellent quality of life after total correction of Fallot tetralogy; however, progressive right ventricular dysfunction requires continuous monitoring, as well as the choice of optimal timing of pulmonary valve replacement.
在过去45年里,法洛四联症的一期修复手术已成功实施。其手术死亡率较低(<5%),长期效果良好。然而,存在延迟性不良反应:右心室进行性扩张和功能障碍、心律失常以及猝死。在我们中心,法洛四联症是最常见的青紫型先天性心脏病形式(包括跨环补片),占所有心血管外科手术的7.5%。现报告中期随访结果。
病例系列研究。该研究纳入了2000年1月至2009年12月期间接受跨环补片法洛四联症完全修复术的患者。对临床变量、发病率和死亡率进行了分析。
该研究中有52例患者,平均年龄4±2岁。围手术期有6例患者死亡,其中5例与残余右心室梗阻相关,1例与再次手术相关。生存率为88%(46例患者),随访时间为75±26个月。14例出现晚期发病,其中11例因右心室功能障碍,2例因远端梗阻复发,1例因残余室间隔缺损。相关危险因素包括严重肺功能不全(p=0.001);QRS>160毫秒,p=0.001);心胸指数>0.60,(p=0.048),以及三尖瓣反流(p=0.001)。
法洛四联症完全矫正术后有合理的长期生存率和良好的生活质量;然而,右心室功能进行性障碍需要持续监测,以及选择肺动脉瓣置换的最佳时机。