理解房水流出在正常及原发性开角型青光眼中作用的最新进展
Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma.
作者信息
Hann Cheryl R, Fautsch Michael P
机构信息
Department of Ophthalmology Mayo Clinic 200 First Street SW Rochester, MN 55905 USA
Department of Ophthalmology Mayo Clinic 200 First Street SW Rochester, MN 55905 USA.
出版信息
Curr Ophthalmol Rep. 2015 Jun 1;3(2):67-73. doi: 10.1007/s40135-015-0072-x.
Primary open angle glaucoma (POAG) is the second leading cause of blindness in the world's rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure. Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor. This article reviews recent research associated with normal and POAG aqueous humor outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand aqueous humor outflow, changes associated with POAG and identify underlying causes of the disease.
原发性开角型青光眼（POAG）是全球人口迅速老龄化背景下导致失明的第二大主要原因。POAG的特征是眼后段神经结构进行性退化，常伴有眼压升高。眼压变化被认为是由房水正常流出受阻所致。本文综述了与正常及POAG房水流出相关的最新研究。文中介绍了阐明POAG受累眼组织生化和病理变化的新发现。干细胞研究、淋巴标记物的鉴定以及小鼠模型使用的增加，为研究人员提供了令人兴奋的新工具，有助于理解房水流出、与POAG相关的变化以及确定该疾病的潜在病因。
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