一名肺梭形细胞癌患者使用卡铂和纳米白蛋白结合型紫杉醇治疗成功。
Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma.
作者信息
Tsuji Takahiro, Kim Young Hak, Ozasa Hiroaki, Sakamori Yuichi, Nagai Hiroki, Ajimizu Hitomi, Yagi Yoshitaka, Furukawa Atsuyuki, Haga Hironori, Mishima Michiaki
机构信息
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
Department of Diagnostic Pathology, Kyoto University Hospital, Japan.
出版信息
Respir Med Case Rep. 2015 May 15;15:48-50. doi: 10.1016/j.rmcr.2015.05.003. eCollection 2015.
INTRODUCTION
Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance.
CASE
A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months.
DISCUSSION
Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC.
引言
肺梭形细胞癌（SpCC）是非小细胞肺癌（NSCLC）的一种罕见亚型，通常具有化疗耐药性。
病例
一名65岁的转移性肺SpCC男性患者最初接受顺铂和多西他赛治疗，但疾病进展。随后，他接受了卡铂和纳米白蛋白结合型紫杉醇（nab-PTX）的联合化疗，之后接受了nab-PTX维持化疗。氟脱氧葡萄糖（FDG）正电子发射断层扫描显示原发肿瘤中FDG摄取大幅减少，且反应持续超过7个月。
讨论
临床前模型表明，nab-PTX可能比溶剂型紫杉醇（sb-PTX）更有效地到达肿瘤微环境，并优先被癌细胞摄取。鉴于肺SpCC患者尚无有效治疗方法，nab-PTX可能值得在肺SpCC患者中进一步研究。
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