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加拿大安大略省慢性阻塞性肺疾病(COPD)患者的社会经济地位、性别、年龄与药物可及性

Socioeconomic Status, Sex, Age and Access to Medications for COPD in Ontario, Canada.

作者信息

Gershon Andrea, Campitelli Michael A, Hwee Jeremiah, Croxford Ruth, To Teresa, Stanbrook Matthew B, Upshur Ross, Stephenson Anne, Stukel Thérèse A

机构信息

a Institute for Clinical Evaluative Sciences , Toronto , Ontario , Canada.

b Sunnybrook Health Sciences Centre , Toronto , Ontario , Canada.

出版信息

COPD. 2015;12(6):668-79. doi: 10.3109/15412555.2015.1020148.

Abstract

Disparities in COPD health outcomes have been found with older individuals, men and those of lower socioeconomic status doing worse. We sought to determine if this was due to differences in access to COPD medications. We conducted a retrospective cohort study using population health administrative data from Ontario, Canada, a province with universal prescription drug coverage for older adults. All individuals with COPD aged 67 years and older in 2008 who were not taking inhaled long-acting bronchodilators or inhaled corticosteroids were followed for 2 years. Poisson regression was used to determine the effects of age, sex, and socioeconomic status on the likelihood of initiating one of these medications, after adjusting for potential confounders. Over the study period, 54,050 of 185,698 (29.1%) older individuals with COPD not previously taking any inhaled long-acting bronchodilators or corticosteroids were initiated on one or more of these medications. After adjustment, individuals of low socioeconomic status, measured using neighborhood income level quintiles, were slightly more likely to initiate COPD medications than those of high socioeconomic status (relative risk (RR) 1.05; 95% confidence interval (95% CI) 1.02-1.08). While men received COPD medication at a consistent rate across all age groups, the likelihood that a woman received medication decreased with increasing age. With the exception of older women, there was minimal disparity in prescription for COPD medications. Disparity in health outcomes among Ontario COPD patients is not clearly explained by differences in medication access by socioeconomic status, sex or age.

摘要

慢性阻塞性肺疾病(COPD)健康结局的差异在老年人、男性以及社会经济地位较低的人群中更为明显。我们试图确定这是否是由于获得COPD药物的机会不同所致。我们利用加拿大安大略省的人口健康管理数据进行了一项回顾性队列研究,该省为老年人提供全民处方药保险。对2008年所有年龄在67岁及以上且未使用吸入长效支气管扩张剂或吸入性糖皮质激素的COPD患者进行了为期2年的随访。在调整潜在混杂因素后,使用泊松回归来确定年龄、性别和社会经济地位对开始使用这些药物之一的可能性的影响。在研究期间,185,698名未使用过任何吸入长效支气管扩张剂或糖皮质激素的老年COPD患者中,有54,050名(29.1%)开始使用了一种或多种此类药物。调整后,使用邻里收入水平五分位数衡量的社会经济地位较低的个体比社会经济地位较高的个体更有可能开始使用COPD药物(相对风险(RR)1.05;95%置信区间(95%CI)1.02 - 1.08)。虽然男性在所有年龄组中接受COPD药物治疗的比例一致,但女性接受药物治疗的可能性随着年龄的增长而降低。除老年女性外,COPD药物处方的差异极小。安大略省COPD患者健康结局的差异并不能通过社会经济地位、性别或年龄在药物获取方面的差异得到明确解释。

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