Butler Andrew A, Burris Thomas P
Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Cell Metab. 2015 Aug 4;22(2):197-8. doi: 10.1016/j.cmet.2015.07.014.
The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior. A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating tissue-specific metabolic processes.
分子时钟是昼夜节律细胞过程的主控制器,这些过程会影响生长、代谢稳态和行为。张等人(2015年)发表在《科学》杂志上的一篇报告重新定义了我们对Rev-erba如何作为一种内部反馈抑制剂发挥作用的理解,该抑制剂在调节核心时钟活性的同时,还能调节组织特异性代谢过程。