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血脂异常诊断惰性:西班牙预防计划的结果。

Diagnostic inertia in dyslipidaemia: results of a preventative programme in Spain.

机构信息

Department of Clinical Medicine, Miguel Hernández University , San Juan de Alicante , Spain.

Department of Pharmacology, Paediatrics and Organic Chemistry, Miguel Hernández University , San Juan de Alicante , Spain.

出版信息

PeerJ. 2015 Jul 28;3:e1109. doi: 10.7717/peerj.1109. eCollection 2015.

Abstract

Others have analysed the relationship between inadequate behaviour by healthcare professionals in the diagnosis of dyslipidaemia (diagnostic inertia) and the history of cardiovascular risk factors. However, since no study has assessed cardiovascular risk scores as associated factors, we carried out a study to quantify diagnostic inertia in dyslipidaemia and to determine if cardiovascular risk scores are associated with this inertia. In the Valencian Community (Spain), a preventive programme (cardiovascular, gynaecologic and vaccination) was started in 2003 inviting persons aged ≥40 years to undergo a health check-up at their health centre. This cross-sectional study examined persons with no known dyslipidaemia seen during the first six months of the programme (n = 16, 905) but whose total cholesterol (TC) was ≥5.17 mmol/L. Diagnostic inertia was defined as lack of follow-up to confirm/discard the dyslipidaemia diagnosis. Other variables included in the analysis were gender, history of cardiovascular risk factors/cardiovascular disease, counselling (diet/exercise), body mass index (BMI), age, blood pressure, fasting blood glucose and lipids. TC was grouped as ≥/<6.20 mmol/L. In patients without cardiovascular disease and <75/≤65 years (n = 15, 778/13, 597), the REGICOR (REgistre GIroní del COr)/SCORE (Systematic COronary Risk Evaluation) cardiovascular risk functions were used to classify risk (high/low). Inertia was quantified and the adjusted odds ratios calculated from multivariate models. In the overall sample, the rate of diagnostic inertia was 52% (95% CI [51.2-52.7]); associated factors were TC ≥ 6.20 mmol/L, high or "not measured" BMI, hypertension, smoking and higher values of fasting blood glucose, systolic blood pressure and TC. In the REGICOR sample, the rate of diagnostic inertia was 51.9% (95% CI [51.1-52.7]); associated factors were REGICOR high and high or "not measured" BMI. In the SCORE sample the rate of diagnostic inertia was 51.7% (95% CI [50.9-52.5]); associated factors were SCORE high and high or "not measured" BMI. Diagnostic inertia existed in over half the patients and was associated with a greater cardiovascular risk.

摘要

其他人分析了医疗保健专业人员在诊断血脂异常(诊断惰性)方面的不当行为与心血管危险因素史之间的关系。然而,由于没有研究评估心血管风险评分作为相关因素,我们进行了一项研究,以量化血脂异常的诊断惰性,并确定心血管风险评分是否与这种惰性相关。在西班牙巴伦西亚社区(Spain),自 2003 年以来启动了一项预防计划(心血管、妇科和疫苗接种),邀请≥40 岁的人在其健康中心进行健康检查。这项横断面研究检查了在该计划的前六个月期间未被发现患有已知血脂异常的患者(n=16905 人),但这些患者的总胆固醇(TC)≥5.17mmol/L。诊断惰性被定义为未进行随访以确认/排除血脂异常诊断。分析中还包括其他变量,如性别、心血管危险因素/心血管疾病史、咨询(饮食/运动)、体重指数(BMI)、年龄、血压、空腹血糖和血脂。TC 分为≥/<6.20mmol/L。在无心血管疾病且年龄<75/<=65 岁的患者中(n=15,778/13,597),使用 REGICOR(GIroní 心血管风险登记处/系统冠状动脉风险评估)心血管风险函数对风险进行分类(高/低)。定量了惰性,并从多变量模型计算了调整后的优势比。在整个样本中,诊断惰性的发生率为 52%(95%CI[51.2-52.7]);相关因素是 TC≥6.20mmol/L、高或“未测量”BMI、高血压、吸烟以及空腹血糖、收缩压和 TC 值较高。在 REGICOR 样本中,诊断惰性的发生率为 51.9%(95%CI[51.1-52.7]);相关因素是 REGICOR 高和高或“未测量”BMI。在 SCORE 样本中,诊断惰性的发生率为 51.7%(95%CI[50.9-52.5]);相关因素是 SCORE 高和高或“未测量”BMI。超过一半的患者存在诊断惰性,且与更高的心血管风险相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe1/4525685/e3397524e2e0/peerj-03-1109-g001.jpg

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