Rosa Maria Inês da, Souza Suéli L, Farias Bruna F de, Pires Patrícia D S, Dondossola Eduardo R, dos Reis Maria Eduarda F
University of Extremo Sul Catarinense, Criciúma, SC, BR.
An Acad Bras Cienc. 2015 Aug;87(2 Suppl):1415-20. doi: 10.1590/0001-3765201520140701. Epub 2015 Aug 4.
We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001).This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.
我们进行了一项系统评价，目的是验证与安慰剂组相比，局部使用5%阿昔洛韦-1%氢化可的松乳膏治疗唇疱疹的疗效。我们使用MEDLINE、Embase、BIOSIS、LILACS、Scopus、灰色文献、Cochrane对照试验中央登记册、ISI科学网和IBECS从1990年至2014年6月进行了文献检索。我们使用相对危险度（RR）及95%置信区间报告结果。文献检索产生了180篇可能相关的出版物。对参考文献列表的回顾又产生了两篇引文。在这些论文中，两篇被认为符合纳入本评价的条件。两项试验共纳入1213例患者。对这些研究的荟萃分析显示RR = 0.77，（95%CI 0.70 - 0.86；p<0.001）。这一结果表明，早期采用抗病毒药物和类固醇联合治疗对唇疱疹治疗有益。
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