血管疾病风险增加的老年受试者脑微结构变化与认知之间的关联。
Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease.
作者信息
Sala Michiel, de Roos Albert, Blauw Gerard J, Middelkoop Huub A M, Jukema J Wouter, Mooijaart Simon P, van Buchem Mark A, de Craen Anton J M, van der Grond Jeroen
机构信息
Department of Radiology, C3-Q, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
Gerontology and Geriatrics, Leiden, The Netherlands.
出版信息
BMC Neurol. 2015 Aug 7;15:133. doi: 10.1186/s12883-015-0396-z.
BACKGROUND
The purpose of this study is to investigate whether changes in brain microstructure, detected by magnetization transfer imaging, are associated with cognition in older subjects at increased risk for vascular disease.
METHODS
One hundred ninety three nondemented subjects (105 men, mean age 77 ± 3 years) from the Prospective Study of Pravastatin in the Elderly at Risk were included. To assess cross-sectional associations between magnetization transfer ratio (MTR) peak height and cognitive test scores, general linear model multivariate analysis was performed. Models were adjusted for age, sex, education level, vascular risk factors, individual white matter lesion volume, and brain atrophy. A repeated measures general linear model was used to investigate whether MTR peak height relates to cognitive test performance at baseline and 3.3-year follow-up.
RESULTS
Cross-sectionally, MTR peak height was associated with performance on the STROOP test (unstandardized β = -0.27, p = 0.045), delayed Picture Word Learning (PWL) test (β = 0.48, p = 0.007), and the Letter Digit Coding test (β = 1.1, p = 0.006). Repeated measures general linear model analysis showed that individuals with low MTR peak height at baseline performed worse on the STROOP test compared to subjects with intermediate MTR peak height (mean time to complete the test at baseline and follow-up, lower versus middle tertile of MTR peak height: 61.6 versus 52.7 s, p = 0.019) or compared to subjects with high MTR peak height (p = 0.046). Similarly, low MTR peak height was associated with worse performance on the immediate (lower versus middle tertile, p = 0.023; lower versus higher tertile, p = 0.032) and delayed PWL test (lower versus middle, p = 0.004; lower versus higher, p = 0.012) at baseline and follow-up testing.
CONCLUSIONS
MTR peak height is associated with cognitive function in older subjects at increased risk for vascular disease.
背景
本研究旨在调查通过磁化传递成像检测到的脑微观结构变化是否与血管疾病风险增加的老年受试者的认知功能相关。
方法
纳入了来自“老年高危人群普伐他汀前瞻性研究”的193名非痴呆受试者（105名男性，平均年龄77±3岁）。为了评估磁化传递率（MTR）峰值高度与认知测试分数之间的横断面关联，进行了一般线性模型多变量分析。模型对年龄、性别、教育水平、血管危险因素、个体白质病变体积和脑萎缩进行了校正。采用重复测量一般线性模型来研究MTR峰值高度是否与基线和3.3年随访时的认知测试表现相关。
结果
横断面分析中，MTR峰值高度与斯特鲁普测试表现相关（非标准化β=-0.27，p=0.045）、延迟图片-单词学习（PWL）测试（β=0.48，p=0.007）以及字母数字编码测试（β=1.1，p=0.006）。重复测量一般线性模型分析显示，与MTR峰值高度处于中等水平的受试者相比（基线和随访时完成测试的平均时间，MTR峰值高度低三分位数与中三分位数：61.6秒对52.7秒，p=0.019），或与MTR峰值高度高的受试者相比（p=0.046），基线时MTR峰值高度低的个体在斯特鲁普测试中的表现更差。同样，在基线和随访测试中，MTR峰值高度低与即时PWL测试（低三分位数与中三分位数，p=0.023；低三分位数与高三分位数，p=0.032）和延迟PWL测试（低三分位数与中三分位数，p=0.004；低三分位数与高三分位数，p=0.012）表现更差相关。
结论
MTR峰值高度与血管疾病风险增加的老年受试者的认知功能相关。
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