多能干细胞与骨骼再生——前景与潜力
Pluripotent Stem Cells and Skeletal Regeneration--Promise and Potential.
作者信息
Wu Joy Y
机构信息
Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Dr., S-025, Stanford, CA, 94305, USA,
出版信息
Curr Osteoporos Rep. 2015 Oct;13(5):342-50. doi: 10.1007/s11914-015-0285-9.
Abstract
The bone is a regenerative tissue, capable of healing itself after fractures. However, some circumstances such as critical-size defects, malformations, and tumor destruction may exceed the skeleton's capacity for self-repair. In addition, bone mass and strength decline with age, leading to an increase in fragility fractures. Therefore, the ability to generate large numbers of patient-specific osteoblasts would have enormous clinical implications for the treatment of skeletal defects and diseases. This review will highlight recent advances in the derivation of pluripotent stem cells, and in their directed differentiation towards bone-forming osteoblasts.
摘要
骨骼是一种可再生组织，能够在骨折后自行愈合。然而，某些情况，如临界尺寸缺损、畸形和肿瘤破坏，可能超出骨骼的自我修复能力。此外，骨量和骨强度会随着年龄的增长而下降，导致脆性骨折的发生率增加。因此，生成大量患者特异性成骨细胞的能力对于骨骼缺损和疾病的治疗具有巨大的临床意义。本综述将重点介绍多能干细胞衍生及其向成骨细胞定向分化方面的最新进展。
相似文献
1
Pluripotent Stem Cells and Skeletal Regeneration--Promise and Potential.
Curr Osteoporos Rep. 2015 Oct;13(5):342-50. doi: 10.1007/s11914-015-0285-9.
2
Mesenchymal stem cells from iPS cells facilitate periodontal regeneration.
J Dent Res. 2013 Sep;92(9):833-9. doi: 10.1177/0022034513498258. Epub 2013 Jul 24.
3
Embryonic stem cells and induced pluripotent stem cells for skeletal regeneration.
Tissue Eng Part B Rev. 2014 Oct;20(5):381-91. doi: 10.1089/ten.TEB.2013.0530. Epub 2013 Dec 18.
4
Exploring the application of mesenchymal stem cells in bone repair and regeneration.
J Bone Joint Surg Br. 2011 Apr;93(4):427-34. doi: 10.1302/0301-620X.93B4.25249.
5
Coculture of peripheral blood CD34+ cell and mesenchymal stem cell sheets increase the formation of bone in calvarial critical-size defects in rabbits.
Br J Oral Maxillofac Surg. 2014 Feb;52(2):134-9. doi: 10.1016/j.bjoms.2013.10.004. Epub 2013 Nov 6.
6
From skeletal development to the creation of pluripotent stem cell-derived bone-forming progenitors.
Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). doi: 10.1098/rstb.2017.0218.
7
Enhanced reconstruction of rat calvarial defects achieved by plasma-treated electrospun scaffolds and induced pluripotent stem cells.
Cell Tissue Res. 2013 Dec;354(3):849-60. doi: 10.1007/s00441-013-1693-8. Epub 2013 Aug 18.
8
Clinical applications of mesenchymal stem cells in the treatment of fracture non-union and bone defects.
Curr Stem Cell Res Ther. 2012 Mar;7(2):127-33. doi: 10.2174/157488812799218956.
9
Skeletal stem cells and bone regeneration: translational strategies from bench to clinic.
Proc Inst Mech Eng H. 2010 Dec;224(12):1455-70. doi: 10.1243/09544119JEIM750.
10
Characterization of human ethmoid sinus mucosa derived mesenchymal stem cells (hESMSCs) and the application of hESMSCs cell sheets in bone regeneration.
Biomaterials. 2015 Oct;66:67-82. doi: 10.1016/j.biomaterials.2015.07.013. Epub 2015 Jul 14.
引用本文的文献
1
Protective role of stem cells in POI: Current status and mechanism of action, a review article.
Heliyon. 2023 Dec 6;10(1):e23271. doi: 10.1016/j.heliyon.2023.e23271. eCollection 2024 Jan 15.
2
Gene-repaired iPS cells as novel approach for patient with .
Front Bioeng Biotechnol. 2023 Jun 30;11:1205122. doi: 10.3389/fbioe.2023.1205122. eCollection 2023.
3
3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway.
J Nanobiotechnology. 2021 Dec 20;19(1):437. doi: 10.1186/s12951-021-01138-2.
4
Stem cell imaging through convolutional neural networks: current issues and future directions in artificial intelligence technology.
PeerJ. 2020 Nov 18;8:e10346. doi: 10.7717/peerj.10346. eCollection 2020.
5
Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts.
J Bone Miner Res. 2020 Apr;35(4):698-713. doi: 10.1002/jbmr.3929. Epub 2019 Dec 30.
6
Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration.
Biomaterials. 2019 Mar;196:31-45. doi: 10.1016/j.biomaterials.2018.02.009. Epub 2018 Feb 5.
7
In Vivo Rescue of the Hematopoietic Niche By Pluripotent Stem Cell Complementation of Defective Osteoblast Compartments.
Stem Cells. 2017 Oct;35(10):2150-2159. doi: 10.1002/stem.2670. Epub 2017 Aug 2.
本文引用的文献
1
Embryonic stem cell-derived osteocytes are capable of responding to mechanical oscillatory hydrostatic pressure.
J Biomech. 2015 Jul 16;48(10):1915-21. doi: 10.1016/j.jbiomech.2015.04.015. Epub 2015 Apr 16.
2
Modeling familial cancer with induced pluripotent stem cells.
Cell. 2015 Apr 9;161(2):240-54. doi: 10.1016/j.cell.2015.02.045.
3
Direct lineage reprogramming: strategies, mechanisms, and applications.
Cell Stem Cell. 2015 Feb 5;16(2):119-34. doi: 10.1016/j.stem.2015.01.013.
4
Promoting effect of 1,25(OH)2 vitamin D3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells.
Open Biol. 2015 Feb;5(2):140201. doi: 10.1098/rsob.140201.
5
Optimized osteogenic differentiation protocol from R1 mouse embryonic stem cells in vitro.
Differentiation. 2015 Jan-Feb;89(1-2):1-10. doi: 10.1016/j.diff.2014.12.003. Epub 2015 Jan 19.
6
A comparison of non-integrating reprogramming methods.
Nat Biotechnol. 2015 Jan;33(1):58-63. doi: 10.1038/nbt.3070. Epub 2014 Dec 1.
7
BMP-4 increases activin A gene expression during osteogenic differentiation of mouse embryonic stem cells.
Growth Factors. 2015 Apr;33(2):133-8. doi: 10.3109/08977194.2014.984805. Epub 2014 Nov 21.
8
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.
Science. 2014 Aug 22;345(6199):1247391. doi: 10.1126/science.1247391.
9
A Site-Specific Integrated Col2.3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells.
Stem Cells Transl Med. 2014 Oct;3(10):1125-37. doi: 10.5966/sctm.2013-0128. Epub 2014 Aug 13.
10
Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions.
Stem Cell Reports. 2014 May 22;2(6):751-60. doi: 10.1016/j.stemcr.2014.04.016. eCollection 2014 Jun 3.
Zotero 插件