双麦芽醇氧钒（BMOV）与大鼠缺血/再灌注诱导的急性肾损伤
Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats.
作者信息
Almac Emre, Bezemer Rick, Kandil Asli, Aksu Ugur, Milstein Dan Mj, Bakker Jan, Demirci-Tansel Cihan, Ince Can
机构信息
Department of Intensive Care Adults, Erasmus MC University Medical Center Rotterdam, Center Rotterdam, PO Box 2040, Rotterdam, 3000 CA, The Netherlands,
出版信息
Intensive Care Med Exp. 2014 Dec;2(1):3. doi: 10.1186/2197-425X-2-3. Epub 2014 Feb 27.
BACKGROUND
The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia).
METHODS
Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function.
RESULTS
The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption.
CONCLUSIONS
Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury.
背景
本研究的目的是在肾缺血/再灌注（缺血30分钟）的情况下，测试有机钒盐双（麦芽醇）氧钒（BMOV；15毫克/千克）的潜在保护作用，及其对再灌注急性期（缺血后长达90分钟）肾氧合和肾功能的影响。
方法
通过夹闭肾动脉，在麻醉并机械通气的雄性Wistar大鼠中建立缺血模型。使用磷光法测量肾微血管和静脉氧合。肌酐清除率、钠重吸收和肾氧处理效率被视为肾功能指标。
结果
主要发现是BMOV不影响全身和肾血流动力学及氧合变量，并部分保护了肾钠重吸收。
结论
用有机钒化合物BMOV预处理不能保护肾脏免受缺血/再灌注损伤。
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