PI3K 抑制剂 AKT1 去磷酸化：需要多少种磷酸酶才能关闭 PI3K？
PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA.
Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA.
出版信息
Cancer Cell. 2015 Aug 10;28(2):143-5. doi: 10.1016/j.ccell.2015.07.010.
PMID:26267528
Abstract
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.
摘要
在本期《癌细胞》杂志中，Ooms 及其同事表明，三阴性乳腺癌中经常失活的脂质磷酸酶 PIPP/INPP5J 通过在致癌性 PI3K 信号的背景下特异性调节 AKT1 的活性，从而抑制转移播散，作为肿瘤抑制因子发挥作用。
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