白细胞介素-15受体α是肌肉燃料利用的一个决定因素，其缺失可预防肥胖。
IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity.
作者信息
Loro Emanuele, Seifert Erin L, Moffat Cynthia, Romero Freddy, Mishra Manoj K, Sun Zheng, Krajacic Predrag, Anokye-Danso Frederick, Summer Ross S, Ahima Rexford S, Khurana Tejvir S
机构信息
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania;
Department of Pathology, Anatomy, and Cell Biology and MitoCare Center, Thomas Jefferson University, Philadelphia, Pennsylvania;
出版信息
Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R835-44. doi: 10.1152/ajpregu.00505.2014. Epub 2015 Aug 12.
IL-15Rα is the widely expressed primary binding partner for IL-15. Because of the wide distribution in nonlymphoid tissues like skeletal muscle, adipose, or liver, IL-15/IL-15Rα take part in physiological and metabolic processes not directly related to immunity. In fast muscle, lack of IL-15Rα promotes an oxidative switch, with increased mitochondrial biogenesis and fatigue resistance. These effects are predicted to reproduce some of the benefits of exercise and, therefore, improve energy homeostasis. However, the direct effects of IL-15Rα on metabolism and obesity are currently unknown. We report that mice lacking IL-15Rα (IL-15Rα(-/-)) are resistant to diet-induced obesity (DIO). High-fat diet-fed IL-15Rα(-/-) mice have less body and liver fat accumulation than controls. The leaner phenotype is associated with increased energy expenditure and enhanced fatty acid oxidation by muscle mitochondria. Despite being protected against DIO, IL-15Rα(-/-) are hyperglycemic and insulin-resistant. These findings identify novel roles for IL-15Rα in metabolism and obesity.
白细胞介素15受体α（IL-15Rα）是白细胞介素15（IL-15）广泛表达的主要结合伴侣。由于其在骨骼肌、脂肪或肝脏等非淋巴组织中的广泛分布，IL-15/IL-15Rα参与了与免疫无直接关系的生理和代谢过程。在快肌中，缺乏IL-15Rα会促进氧化转换，增加线粒体生物合成并增强抗疲劳能力。预计这些作用会重现运动的一些益处，从而改善能量稳态。然而，IL-15Rα对代谢和肥胖的直接影响目前尚不清楚。我们报告，缺乏IL-15Rα的小鼠（IL-15Rα(-/-)）对饮食诱导的肥胖（DIO）具有抗性。高脂饮食喂养的IL-15Rα(-/-)小鼠的体脂和肝脂肪积累比对照组少。较瘦的表型与能量消耗增加和肌肉线粒体脂肪酸氧化增强有关。尽管受到保护免受DIO影响，但IL-15Rα(-/-)小鼠存在高血糖和胰岛素抵抗。这些发现确定了IL-15Rα在代谢和肥胖中的新作用。
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