胰岛素样生长因子-1水平与垂直面部生长的纵向关系。
Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth.
作者信息
Masoud Mohamed I, Marghalani Hussain Y A, Alamoudi Najlaa M, El Derw Douaa, Masoud Ibrahim M, Gowharji Nour F
机构信息
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, 02115, Boston, MA, USA.
Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
J Orofac Orthop. 2015 Sep;76(5):440-50. doi: 10.1007/s00056-015-0305-5.
BACKGROUND
Facial growth in the vertical dimension is the last to be completed and can often be detrimental to the success of dental implants, orthodontic treatment, and orthognathic surgery that young individuals undergo.
AIM
The purpose of this study was to evaluate the longitudinal relationship between changes in total anterior facial height and insulin-like growth factor-1 (IGF-1) levels measured using blood-spot samples.
METHODS
Our sample included 25 orthodontic patients from whom we had access to annual lateral cephalometric radiographs and IGF-1 measurements. Each subject was observed between 2 and 6 times, resulting in 43 annual intervals from a total of 77 observations.
RESULTS
We noted a significant moderate positive correlation (+ 0.48) between the percentage of change in blood-spot IGF-1 levels and the percentage of change in total anterior face height (p = 0.01).
CONCLUSION
Longitudinal changes in IGF-1 levels can be used to predict a patient's vertical facial growth. There was no significant correlation between changes in vertical facial development and a single cross-sectional IGF-1 measurement.
背景
面部垂直方向的生长是最后完成的，并且常常会对年轻人接受的牙种植、正畸治疗和正颌手术的成功产生不利影响。
目的
本研究的目的是评估使用血斑样本测量的总前牙面高度变化与胰岛素样生长因子-1（IGF-1）水平之间的纵向关系。
方法
我们的样本包括25名正畸患者，我们可以获得他们每年的头颅侧位X线片和IGF-1测量值。每个受试者被观察2至6次，总共77次观察产生了43个年度间隔。
结果
我们注意到血斑IGF-1水平变化百分比与总前牙面高度变化百分比之间存在显著的中度正相关（+0.48）（p = 0.01）。
结论
IGF-1水平的纵向变化可用于预测患者的面部垂直生长。面部垂直发育变化与单次横断面IGF-1测量之间无显著相关性。
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