来自不同供体和物种的骨髓间充质干/基质细胞之间的共同点是什么？
Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
作者信息
Jones Elena, Schäfer Richard
机构信息
Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds University, Room 5.24 Clinical Sciences Building, St James's University Hospital, Leeds, LS9 7TF, UK.
Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Donor Service, Baden-Württemberg-Hessen gGmbH, Johann-Wolfgang-Goethe University Hospital, Sandhofstrasse 1, D-60528, Frankfurt am Main, Germany.
出版信息
Stem Cell Res Ther. 2015 Aug 18;6(1):143. doi: 10.1186/s13287-015-0144-8.
Abstract
Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC characterization and potency assays as well as for MSC study comparability and manufacturing. This review discusses promising marker combinations for prospective MSC subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. In order to address animal modelling in MSC biology, comparison of mouse and human MSC markers highlights current common ground of MSCs between species.
摘要
间充质干/基质细胞（MSC）在细胞治疗方面具有广阔的应用前景，但由于体内和体外MSC存在显著的异质性，MSC治疗方法和检测技术的发展受到了严重阻碍。这种异质性给MSC特性鉴定和效能检测的标准化以及MSC研究的可比性和生产制造带来了挑战。本文综述了用于富集和扩增预期MSC亚群的有前景的标志物组合，并探讨了环境和年龄导致的MSC表型变化。为了解决MSC生物学中的动物建模问题，对小鼠和人类MSC标志物的比较突出了不同物种间MSC目前的共同特征。
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