Hiligsmann Mickaël, Bours Sandrine P G, Boonen Annelies
Department of Health Services Research, School for Public Health and Primary Care (CAPHRI), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands,
Curr Rheumatol Rep. 2015 Sep;17(9):61. doi: 10.1007/s11926-015-0533-0.
Poor medication adherence is a major problem in chronic diseases such as osteoporosis that may partially be due to unaddressed patient values and preferences. Data on patient preferences could help clinicians to improve medication adherence and could also be useful in policy decisions and guideline development. This paper aims to identify literature reporting on the preferences of patients for osteoporosis drug medications. Several methods have been used to elicit patient preferences for medications and their characteristics including qualitative research, survey with ranking/rating exercises, discrete-choice experiments and clinical studies (crossover designs, open-label study). All these studies revealed that osteoporotic patients have preferences for medications and their attributes, in particular for less-frequent dosing regimens. Interestingly, variations in the preferences of patients were observed in most studies, suggesting the importance to take into account individual preference in decision-making to improve osteoporosis care.
药物依从性差是骨质疏松症等慢性病中的一个主要问题,这可能部分归因于患者的价值观和偏好未得到解决。关于患者偏好的数据可以帮助临床医生提高药物依从性,也有助于政策决策和指南制定。本文旨在识别有关患者对骨质疏松症药物偏好的文献报道。已经使用了几种方法来引出患者对药物及其特性的偏好,包括定性研究、带有排序/评分练习的调查、离散选择实验和临床研究(交叉设计、开放标签研究)。所有这些研究都表明,骨质疏松症患者对药物及其属性有偏好,特别是对给药频率较低的治疗方案。有趣的是,在大多数研究中都观察到了患者偏好的差异,这表明在决策过程中考虑个体偏好对于改善骨质疏松症护理的重要性。