Li Hong-Hua, Shan Ling, Du Lin, Jia Fei-Yong
Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun 130021, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug;17(8):886-92.
Autism spectrum disorders (ASD) are a group of developmental dysfuntion of nervous system characterized by social interaction and communication disorders, restricted interests and repetitive stereotyped behaviors. The incidence of ASD has been increasing through the world. Some studies have shown that early reasonable individualized comprehensive intervention can obviously improve the prognosis of children with ASD. The etiology of ASD is unclear now, and behavioral and developmental intervention is the main therapy for ASD. The reasonable application of some drugs can improve the efficacy of the behavioral intervention for concomitant symptoms in ASD. With the in-depth study of the pathogenesis of ASD, bumetanide, oxytocin, vitamin D and hyperbaric oxygen therapy have been found to be promising for the improvement of core symptoms of ASD. This article reviews the research advances in the behavioral and developmental intervention and drug therapy for ASD.
自闭症谱系障碍(ASD)是一组以社交互动和沟通障碍、兴趣局限及重复刻板行为为特征的神经系统发育功能障碍。ASD在全球的发病率一直在上升。一些研究表明,早期合理的个体化综合干预可显著改善ASD患儿的预后。目前ASD的病因尚不清楚,行为和发育干预是ASD的主要治疗方法。合理应用一些药物可提高对ASD伴随症状的行为干预效果。随着对ASD发病机制研究的深入,发现布美他尼、催产素、维生素D和高压氧治疗在改善ASD核心症状方面具有前景。本文综述了ASD行为和发育干预及药物治疗的研究进展。