Vlam L, Stam M, de Jager W, Cats E A, van den Berg L H, van der Pol W L
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Pediatric Immunology, Multiplex Core Facility, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
J Neuroimmunol. 2015 Sep 15;286:1-4. doi: 10.1016/j.jneuroim.2015.06.008. Epub 2015 Jun 20.
Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.
多灶性运动神经病（MMN）和进行性肌肉萎缩（PMA）与IgM单克隆丙种球蛋白病或IgM抗GM1抗体的存在有关。为了进一步研究MMN和PMA的病理生理学，我们测定了25例MMN患者、55例PMA患者、25例肌萎缩侧索硬化症（ALS）患者和50名健康对照者血清中16种主要与B细胞相关的炎症标志物的浓度。无论是否存在IgM单克隆丙种球蛋白病或高IgM抗GM1抗体，MMN患者或PMA患者中16种检测的细胞因子和趋化因子的血清中位数浓度均未显著升高。这些结果表明，MMN和PMA发病机制中不存在系统性B细胞介导的免疫反应。
