在瑞典，同时使用两种或更多种抗精神病药物的情况很常见。
Concomitant use of two or more antipsychotic drugs is common in Sweden.
作者信息
Bergendal Annica, Schiöler Helena, Wettermark Björn, Björkstén Karin Sparring
机构信息
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, Huddinge, C1:68, SE-141 86 Stockholm, Sweden.
National Board of Health and Welfare, SE-106 30 Stockholm, Sweden.
出版信息
Ther Adv Psychopharmacol. 2015 Aug;5(4):224-31. doi: 10.1177/2045125315588647.
OBJECTIVES
To assess the prevalence of concomitant use of two or more antipsychotic drugs and other psychotropic drugs in the Swedish population.
METHODS
Data for this observational cohort study were collected from the Swedish Prescribed Drug Register including all dispensed drugs to the entire Swedish population (9.4 million inhabitants). We identified all individuals with at least one dispensed prescription of antipsychotic drug during January to June 2008. After 12 months, a second exposure period was chosen. Individuals who were dispensed two or more antipsychotic drugs in both periods were considered long-time users of antipsychotic polypharmacy.
RESULTS
In 2008, 1.5% of the Swedish population was dispensed antipsychotic drugs, the majority (75%) using only one antipsychotic drug. Out of individuals who were dispensed 2 or more antipsychotic drugs during the first period, 62% also was also dispensed at least 2 antipsychotic drugs during the second period. A total of 665 different unique combinations were used in 2008. Individuals prescribed two or more antipsychotic drugs during both periods were more often dispensed anxiolytics and sedatives than those who were dispensed only one antipsychotic drug. Elderly were dispensed antipsychotic drugs much more often than younger persons.
CONCLUSIONS
In Sweden, 25% of patients dispensed antipsychotic drugs receive a combination of two or more antipsychotic drugs. Individuals who are dispensed antipsychotic polypharmacy are more often dispensed anxiolytics and sedatives than those prescribed only one antipsychotic drug. Long-term observational studies are needed to assess the efficacy and safety of such combinations.
目的
评估瑞典人群中同时使用两种或更多抗精神病药物及其他精神药物的情况。
方法
这项观察性队列研究的数据收集自瑞典处方药登记处，涵盖了向全体瑞典人口（940万居民）发放的所有药物。我们确定了在2008年1月至6月期间至少有一张抗精神病药物处方的所有个体。12个月后，选择第二个暴露期。在两个时期都被发放两种或更多抗精神病药物的个体被视为抗精神病药物联合使用的长期使用者。
结果
2008年，1.5%的瑞典人口被发放了抗精神病药物，大多数（75%）仅使用一种抗精神病药物。在第一个时期被发放2种或更多抗精神病药物的个体中，62%在第二个时期也被发放了至少2种抗精神病药物。2008年共使用了665种不同的独特组合。在两个时期都被开了两种或更多抗精神病药物的个体比仅被发放一种抗精神病药物的个体更常被发放抗焦虑药和镇静剂。老年人比年轻人更常被发放抗精神病药物。
结论
在瑞典，25%接受抗精神病药物治疗的患者同时接受两种或更多抗精神病药物的联合治疗。与仅被开一种抗精神病药物的个体相比，接受抗精神病药物联合治疗的个体更常被发放抗焦虑药和镇静剂。需要进行长期观察性研究来评估此类联合用药的疗效和安全性。
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